Artículos de revistas
ORESTES are enriched in rare exon usage variants affecting the encoded proteins
Registro en:
Comptes Rendus Biologies. Elsevier France-editions Scientifiques Medicales Elsevier, v. 326, n. 41953, n. 979, n. 985, 2003.
1631-0691
WOS:000187997400013
10.1016/j.crvi.2003.09.027
Autor
Sakabe, NJ
de Souza, JES
Galante, PAF
de Oliveira, PSL
Passetti, F
Brentani, H
Osorio, EC
Zaiats, AC
Leerkes, MR
Kitajima, JP
Brentani, RR
Strausberg, RL
Simpson, AJG
de Souza, SJ
Institución
Resumen
A significant fraction of the variability found in the human transcriptome is due to alternative splicing, including alternative exon usage (AEU), intron retention and use of cryptic splice sites. We present a comparison of a large-scale analysis of AEU in the human transcriptome through genome mapping of Open Reading Frame ESTs (ORESTES) and conventional ESTs. It is shown here that ORESTES probe low abundant messages more efficiently. In addition, most of the variants detected by ORESTES affect the structure of the corresponding proteins. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved. 326 41953 979 985