ORESTES are enriched in rare exon usage variants affecting the encoded proteins

dc.creatorSakabe, NJ
dc.creatorde Souza, JES
dc.creatorGalante, PAF
dc.creatorde Oliveira, PSL
dc.creatorPassetti, F
dc.creatorBrentani, H
dc.creatorOsorio, EC
dc.creatorZaiats, AC
dc.creatorLeerkes, MR
dc.creatorKitajima, JP
dc.creatorBrentani, RR
dc.creatorStrausberg, RL
dc.creatorSimpson, AJG
dc.creatorde Souza, SJ
dc.date2003
dc.dateOCT-NOV
dc.date2014-11-14T03:55:36Z
dc.date2015-11-26T16:04:18Z
dc.date2014-11-14T03:55:36Z
dc.date2015-11-26T16:04:18Z
dc.date.accessioned2018-03-28T22:53:24Z
dc.date.available2018-03-28T22:53:24Z
dc.identifierComptes Rendus Biologies. Elsevier France-editions Scientifiques Medicales Elsevier, v. 326, n. 41953, n. 979, n. 985, 2003.
dc.identifier1631-0691
dc.identifierWOS:000187997400013
dc.identifier10.1016/j.crvi.2003.09.027
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69733
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69733
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69733
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265448
dc.descriptionA significant fraction of the variability found in the human transcriptome is due to alternative splicing, including alternative exon usage (AEU), intron retention and use of cryptic splice sites. We present a comparison of a large-scale analysis of AEU in the human transcriptome through genome mapping of Open Reading Frame ESTs (ORESTES) and conventional ESTs. It is shown here that ORESTES probe low abundant messages more efficiently. In addition, most of the variants detected by ORESTES affect the structure of the corresponding proteins. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved.
dc.description326
dc.description41953
dc.description979
dc.description985
dc.languageen
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.publisherParis
dc.publisherFrança
dc.relationComptes Rendus Biologies
dc.relationC. R. Biol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectalternative splicing
dc.subjectalternative exon usage
dc.subjectbioinformatics
dc.subjectgenome mapping
dc.subjectORESTES
dc.subjecthuman transcriptome
dc.subjectExpressed Sequence Tags
dc.subjectPre-messenger-rna
dc.subjectHuman Genome
dc.subjectHuman Genes
dc.subjectHuman Transcriptome
dc.subjectDiversity
dc.titleORESTES are enriched in rare exon usage variants affecting the encoded proteins
dc.typeArtículos de revistas


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