Artículos de revistas
Biotransformation Of α-bromoacetophenones By The Marine Fungus Aspergillus Sydowii
Registro en:
Marine Biotechnology. , v. 12, n. 5, p. 552 - 557, 2010.
14362228
10.1007/s10126-009-9241-y
2-s2.0-77957755661
Autor
Rocha L.C.
Ferreira H.V.
Pimenta E.F.
Berlinck R.G.S.
Rezende M.O.O.
Landgraf M.D.
Seleghim M.H.R.
Sette L.D.
Porto A.L.M.
Institución
Resumen
The biotransformation reactions of α-bromoacetophenone (1), p-bromo-α-bromoacetophenone (2), and p-nitro-α-bromoacetophenone (3) by whole cells of the marine fungus Aspergillus sydowii Ce19 have been investigated. Fungal cells that had been grown in artificial sea water medium containing a high concentration of chloride ions (1.20 M) catalysed the biotransformation of 1 to 2-bromo-1-phenylethanol 4 (56%), together with the α-chlorohydrin 7 (9%), 1-phenylethan-1,2-diol 9 (26%), acetophenone 10 (4%) and phenylethanol 11 (5%) identified by GC-MS analysis. In addition, it was observed that the enzymatic reaction was accompanied by the spontaneous debromination of 1 to yield α-chloroacetophenone 5 (9%) and α-hydroxyacetophenone 6 (18%) identified by GC-FID analysis. When 2 and 3 were employed as substrates, various biotransformation products were detected but the formation of halohydrins was not observed. 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