Artículos de revistas
Endometrial Thickness And Oestradiol Concentration In Women With Bleeding Complaints During Use Of Norplant® Implants
Registro en:
Human Reproduction. , v. 13, n. 1, p. 188 - 191, 1998.
2681161
10.1093/humrep/13.1.188
2-s2.0-2642703413
Autor
Faundes A.-.
Alvarez F.
Brache V.
Cochon L.
Institución
Resumen
The objective of this study was to measure oestradiol, progesterone and endometrial development among Norplant® implant users with bleeding complaints. Seventy-six volunteers complaining of prolonged/frequent bleeding were enrolled. Oestradiol, progesterone and endometrial thickness (assessed by vaginal ultrasound) were determined at that visit. Two thirds of the women had low oestradiol (< 50 pg/ml) and all except one had low progesterone concentrations (< 3 ng/ml). A total of 68% had a very thin endometrium (< 3 mm). A subgroup of 21 women were followed twice a week for 8 consecutive weeks. Oestradiol and progesterone concentrations remained low during the continuous bleeding episodes or short bleeding-free intervals (≤ 15 days), yet increased five- to sixfold (253.4 ± 142.2 pg/ml) in long bleeding-free intervals. Endometrial thickness remained thin irrespective of the differences in bleeding patterns and oestradiol. We conclude that Norplant® implant users with bleeding complaints are usually characterized by low oestradiol concentrations, absence of luteal activity and thin endometrium. A good correlation exists with increasing oestradiol concentrations and longer bleeding-free intervals, but this is not manifested by increased endometrial thickness. However, few subjects bleed with relatively high oestradiol concentrations, therefore a better understanding of the intimate disturbances related to endometrial bleeding in users of long-acting progestins is still pending. 13 1 188 191 Alvarez, F., Brache, V., Thevenin, F., Hormonal treatment for bleeding irregularities in Norplant® implant users (1996) Am. J. Obstet. Gynecol., 174, pp. 919-922 Archer, D.F., Philput, C.A., Weber, M.E., Management of irregular uterine bleeding and spotting associated with Norplant® (1996) Hum. 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