Endometrial Thickness And Oestradiol Concentration In Women With Bleeding Complaints During Use Of Norplant® Implants

dc.creatorFaundes A.-.
dc.creatorAlvarez F.
dc.creatorBrache V.
dc.creatorCochon L.
dc.date1998
dc.date2015-06-30T15:05:15Z
dc.date2015-11-26T15:13:08Z
dc.date2015-06-30T15:05:15Z
dc.date2015-11-26T15:13:08Z
dc.date.accessioned2018-03-28T22:23:15Z
dc.date.available2018-03-28T22:23:15Z
dc.identifier
dc.identifierHuman Reproduction. , v. 13, n. 1, p. 188 - 191, 1998.
dc.identifier2681161
dc.identifier10.1093/humrep/13.1.188
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-2642703413&partnerID=40&md5=e57a0fae8f69a4ed7613cf01fa836a76
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/100543
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/100543
dc.identifier2-s2.0-2642703413
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1258563
dc.descriptionThe objective of this study was to measure oestradiol, progesterone and endometrial development among Norplant® implant users with bleeding complaints. Seventy-six volunteers complaining of prolonged/frequent bleeding were enrolled. Oestradiol, progesterone and endometrial thickness (assessed by vaginal ultrasound) were determined at that visit. Two thirds of the women had low oestradiol (< 50 pg/ml) and all except one had low progesterone concentrations (< 3 ng/ml). A total of 68% had a very thin endometrium (< 3 mm). A subgroup of 21 women were followed twice a week for 8 consecutive weeks. Oestradiol and progesterone concentrations remained low during the continuous bleeding episodes or short bleeding-free intervals (≤ 15 days), yet increased five- to sixfold (253.4 ± 142.2 pg/ml) in long bleeding-free intervals. Endometrial thickness remained thin irrespective of the differences in bleeding patterns and oestradiol. We conclude that Norplant® implant users with bleeding complaints are usually characterized by low oestradiol concentrations, absence of luteal activity and thin endometrium. A good correlation exists with increasing oestradiol concentrations and longer bleeding-free intervals, but this is not manifested by increased endometrial thickness. However, few subjects bleed with relatively high oestradiol concentrations, therefore a better understanding of the intimate disturbances related to endometrial bleeding in users of long-acting progestins is still pending.
dc.description13
dc.description1
dc.description188
dc.description191
dc.descriptionAlvarez, F., Brache, V., Thevenin, F., Hormonal treatment for bleeding irregularities in Norplant® implant users (1996) Am. J. Obstet. Gynecol., 174, pp. 919-922
dc.descriptionArcher, D.F., Philput, C.A., Weber, M.E., Management of irregular uterine bleeding and spotting associated with Norplant® (1996) Hum. Reprod., 11 (SUPPL. 2), pp. 24-30
dc.descriptionAu, C.L., Affandi, B., Rogers, P.A.W., Immunohistochemical staining of von Willebrand factor in endometrium of women during the first year of Norplant® implants use (1994) Contraception, 50, pp. 477-489
dc.descriptionBakos, O., Smith, P., Heimer, G., Ultrasonographical and hormonal description of the normal ovulatory menstrual cycle (1994) Acta Obstet. Gynecol. Scand., 73, pp. 790-796
dc.descriptionCritchley, H.O.D., Bailey, D.A., Au, C.L., Immunohistochemical sex steroid receptor distribution in endometrium from long-term subdermal levonorgestrel users and during the normal menstrual cycle (1993) Hum. Reprod., 8, pp. 1632-1639
dc.descriptionCroxatto, H.D., Diaz, S., Pavez, M., Histopathology of the endometrium during continuous use of levonorgestrel (1984) Long-acting Contraceptive Delivery Systems, pp. 290-295. , Zatuchni, G.I., Goldsmith, A., Shelton, J.D. et al. (eds). Harper and Row, Philadelphia
dc.descriptionDarney, P.D., Taylor, R.N., Klaisle, C., Serum concentration of oestradiol, progesterone, and levonorgestrel are not determinants of endometrial histology or abnormal bleeding in long-term Norplant® implants users (1996) Contraception, 53, pp. 97-100
dc.descriptionDiaz, S., Croxatto, H.B., Pavez, M., Clinical assessment of treatments for prolonged bleeding in users of Norplant® implants (1990) Contraception, 42, pp. 97-109
dc.descriptionFaúndes, A., Alvarez-Sanchez, F., Brache, V., Hormonal changes associated with bleeding during low dose progestogen contraception delivered by Norplant® subdermal implants (1991) Adv. Contracep., 7, pp. 1-10
dc.descriptionFleischer, A.C., Kalemeris, G.C., Machin, J.E., Sonographic depiction of normal and abnormal endometrium with histopathologic correlation (1986) J. Ultrasound Med., 5, pp. 445-452
dc.descriptionGoodger, A.M., Rogers, P.A.W., Affandi, B., Endometrial endothelial cell proliferation in long-term users of subdermal levonorgestrel (1994) Hum. Reprod., 9, pp. 1647-1651
dc.descriptionHadisaputra, W., Affandi, B., Witjaksono, J., Endometrial biopsy collection from women receiving Norplant (1996) Hum. Reprod., 11 (SUPPL. 2), pp. 31-34
dc.descriptionHickey, M., Fraser, I.S., Dwarte, D.D., Graham, S., Endometrial vasculature in Norplant® users: Preliminary results from a hystereoscopic study (1996) Hum. Reprod., 11 (SUPPL. 2), pp. 35-44
dc.descriptionJanne, O., Isomaa, V., Isotalo, H., Uterine estrogen and progestin receptors and their regulation (1978) Upsala J. Med. Sci., 22, pp. 62-70
dc.descriptionJohannisson, E., Brosens, I., Cornilie, F., Morphometric study of the human endometrium following continuous exposure to levonorgestrel release from vaginal rings during 90 days (1991) Contraception, 43, pp. 361-374
dc.descriptionLuukkainen, T., Haukkamaa, M., Concentration of levonorgestrel in endometrium and myometrium after oral and intrauterine administration (1990) Contraception and Mechanisms of Endometrial Bleeding, pp. 181-186. , d'Arcangues, C., Fraser, I.S., Newton, J. et al. (eds). Cambridge University Press, Cambridge
dc.descriptionMaqueo, M., Vascular and perivascular changes in the endometrium of women using steroidal contraceptives (1980) Endometrial Bleeding and Steroidal Contraception, pp. 138-152. , Diczfalusy, E., Fraser, I.S., Webb, F.T.G. (eds). Pitman Press, London
dc.descriptionMarsh, M.M., Butt, A.R., Riley, S.C., Immunolocalization of endothelin and neutral endopeptidase in the endometrium of users of subdermally implanted levonorgestrel (Norplant®) (1995) Hum. Reprod., 10, pp. 2584-2589
dc.descriptionOlsson, S.E., Bakos, O., Lindgren, P.G., Ovarian function during use of subdermal implants releasing low doses of levonorgestrel (1990) Br. J. Fam. Plann., 16, pp. 88-93
dc.descriptionPalmer, J.A., Lau, T.M., Hickley, M., Immunohistochemical study of endometrial microvascular basement membrane components in women using Norplant® (1996) Hum. Reprod., 11, pp. 2142-2150
dc.descriptionRogers, P.A.W., Au, S.L., Affandi, B., Endometrial microvascular density during the normal menstrual cycle and following exposure to long term levonorgestrel (1993) Hum. Reprod., 8, pp. 1396-1404
dc.descriptionShaaban, M.M., Segal, S., Salem, H.T., Sonographic assessment of ovarian and endometrial changes during long-term Norplant® use and their correlation with hormonal concentrations (1993) Fertil. Steril., 59, pp. 998-1002
dc.descriptionSubakir, S.B., Hadisaputra, W., Siregar, B., Reduced endothelial cell migratory signal production by endometrial explants from women using Norplant® contraception (1995) Hum. Reprod., 10, pp. 2579-2583
dc.descriptionWitjaksono, J., Lau, T.M., Affandi, B., Rogers, P.A.W., Oestrogen treatment for increased bleeding in Norplant® users: Preliminary results (1996) Hum. Reprod., 11, pp. 109-114
dc.descriptionWonodirekso, S., Au, C.L., Hadisaputra, W., Cytokeratins 8, 18 and 19 in endometrial epithelial cells during the normal menstrual cycle and in women receiving Norplant® (1993) Contraception, 48, pp. 481-493
dc.descriptionClinical evaluation of the therapeutic effectiveness of ethinyl oestradiol and oestrone sulphate on prolonged bleeding in women using depot medroxyprogesterone acetate for contraception (1996) Hum. Reprod., 11, pp. 1-13
dc.languageen
dc.publisher
dc.relationHuman Reproduction
dc.rightsfechado
dc.sourceScopus
dc.titleEndometrial Thickness And Oestradiol Concentration In Women With Bleeding Complaints During Use Of Norplant® Implants
dc.typeArtículos de revistas


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