Artículos de revistas
Ankhd1, A Novel Component Of The Hippo Signaling Pathway, Promotes Yap1 Activation And Cell Cycle Progression In Prostate Cancer Cells
Registro en:
Experimental Cell Research. Academic Press Inc., v. 324, n. 2, p. 137 - 145, 2014.
144827
10.1016/j.yexcr.2014.04.004
2-s2.0-84901194678
Autor
Machado-Neto J.A.
Lazarini M.
Favaro P.
Franchi G.C.
Nowill A.E.
Saad S.T.O.
Traina F.
Institución
Resumen
ANKHD1 is a multiple ankyrin repeat containing protein, recently identified as a novel member of the Hippo signaling pathway. The present study aimed to investigate the role of ANKHD1 in DU145 and LNCaP prostate cancer cells. ANKHD1 and YAP1 were found to be highly expressed in prostate cancer cells, and ANKHD1 silencing decreased cell growth, delayed cell cycle progression at the S phase, and reduced tumor xenograft growth. Moreover, ANKHD1 knockdown downregulated YAP1 expression and activation, and reduced the expression of CCNA2, a YAP1 target gene. These findings indicate that ANKHD1 is a positive regulator of YAP1 and promotes cell growth and cell cycle progression through Cyclin A upregulation. © 2014 Elsevier Inc. 324 2 137 145 Bao, Y., Hata, Y., Ikeda, M., Withanage, K., Mammalian Hippo pathway: from development to cancer and beyond (2011) J. Biochem., 149, pp. 361-379 Chan, S.W., Lim, C.J., Chen, L., Chong, Y.F., Huang, C., The Hippo pathway in biological control and cancer development (2011) J. Cell Physiol., 226, pp. 928-939 Komuro, A., Nagai, M., Navin, N.E., Sudol, M., WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus (2003) J Biol. Chem., 278, pp. 33334-33341 Espanel, X., Sudol, M., Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains (2001) J. Biol. Chem., 276, pp. 14514-14523 Zaidi, S.K., Sullivan, A.J., Medina, R., Ito, Y., van Wijnen, A.J., Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription (2004) EMBO J., 23, pp. 790-799 Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control (2008) Dev. Cell, 14, pp. 377-387 Wu, S., Liu, Y., Zheng, Y., Dong, J., Pan, D., The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway (2008) Dev. Cell, 14, pp. 388-398 Lapi, E., Di Agostino, S., Donzelli, S., Gal, H., Domany, E., PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop (2008) Mol. Cell, 32, pp. 803-814 Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Elucidation of a universal size-control mechanism in Drosophila and mammals (2007) Cell, 130, pp. 1120-1133 Overholtzer, M., Zhang, J., Smolen, G.A., Muir, B., Li, W., Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 12405-12410 Zhao, B., Wei, X., Li, W., Udan, R.S., Yang, Q., Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control (2007) Genes Dev., 21, pp. 2747-2761 Powzaniuk, M., McElwee-Witmer, S., Vogel, R.L., Hayami, T., Rutledge, S.J., The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor (2004) Mol. Endocrinol., 18, pp. 2011-2023 Poulin, F., Brueschke, A., Sonenberg, N., Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK (2003) J. Biol. Chem., 278, pp. 52290-52297 Sedgwick, S.G., Smerdon, S.J., The ankyrin repeat: a diversity of interactions on a common structural framework (1999) Trends Biochem. Sci., 24, pp. 311-316 Traina, F., Favaro, P.M., Medina Sde, S., Duarte Ada, S., Winnischofer, S.M., ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells (2006) Biochim. Biophys. Acta, 1762, pp. 828-834 Dhyani, A., Duarte, A.S., Machado-Neto, J.A., Favaro, P., Ortega, M.M., ANKHD1 regulates cell cycle progression and proliferation in multiple myeloma cells (2012) FEBS Lett., 586, pp. 4311-4318 Sansores-Garcia, L., Atkins, M., Moya, I.M., Shahmoradgoli, M., Tao, C., Mask is required for the activity of the Hippo pathway effector Yki/YAP (2013) Curr.. Biol., 23, pp. 229-235 Sidor, C.M., Brain, R., Thompson, B.J., Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway (2013) Curr. Biol., 23, pp. 223-228 Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method (2001) Methods, 25, pp. 402-408 Favaro, P., Traina, F., Machado-Neto, J.A., Lazarini, M., Lopes, M.R., FMNL1 promotes proliferation and migration of leukemia cells (2013) J. Leukoc. Biol., 94, pp. 503-512 Ren, Y.R., Patel, K., Paun, B.C., Kern, S.E., Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers (2011) J. Biol. Chem., 286, pp. 11960-11969 Mizuno, T., Murakami, H., Fujii, M., Ishiguro, F., Tanaka, I., YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes (2012) Oncogene, 31, pp. 5117-5122 von Gise, A., Lin, Z., Schlegelmilch, K., Honor, L.B., Pan, G.M., YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy (2012) Proc. Natl. Acad. Sci. USA, 109, pp. 2394-2399 Liu, A.M., Wong, K.F., Jiang, X., Qiao, Y., Luk, J.M., Regulators of mammalian Hippo pathway in cancer (1826) Biochim. Biophys. Acta, 2012, pp. 357-364 Du Toit, A., Cell signalling: a new Hippo pathway component (2013) Nat. Rev. Mol. Cell Biol., 14, p. 196 Enderle, L., McNeill, H., Hippo gains weight: added insights and complexity to pathway control (2013) Sci. Signal., 6, pp. re7 Kalaszczynska, I., Geng, Y., Iino, T., Mizuno, S., Choi, Y., Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells (2009) Cell, 138, pp. 352-365 Geley, S., Kramer, E., Gieffers, C., Gannon, J., Peters, J.M., Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint (2001) J. Cell Biol., 153, pp. 137-148 McNeill, H., Woodgett, J.R., When pathways collide: collaboration and connivance among signalling proteins in development (2010) Nat. Rev. Mol. Cell Biol., 11, pp. 404-413 Fernandez, L.A., Northcott, P.A., Dalton, J., Fraga, C., Ellison, D., YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation (2009) Genes Dev., 23, pp. 2729-2741