Ankhd1, A Novel Component Of The Hippo Signaling Pathway, Promotes Yap1 Activation And Cell Cycle Progression In Prostate Cancer Cells

dc.creatorMachado-Neto J.A.
dc.creatorLazarini M.
dc.creatorFavaro P.
dc.creatorFranchi G.C.
dc.creatorNowill A.E.
dc.creatorSaad S.T.O.
dc.creatorTraina F.
dc.date2014
dc.date2015-06-25T18:03:49Z
dc.date2015-11-26T15:06:07Z
dc.date2015-06-25T18:03:49Z
dc.date2015-11-26T15:06:07Z
dc.date.accessioned2018-03-28T22:16:39Z
dc.date.available2018-03-28T22:16:39Z
dc.identifier
dc.identifierExperimental Cell Research. Academic Press Inc., v. 324, n. 2, p. 137 - 145, 2014.
dc.identifier144827
dc.identifier10.1016/j.yexcr.2014.04.004
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84901194678&partnerID=40&md5=77d7ff65a1ce644a3a1dd2ed67d69a28
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/88073
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/88073
dc.identifier2-s2.0-84901194678
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1257181
dc.descriptionANKHD1 is a multiple ankyrin repeat containing protein, recently identified as a novel member of the Hippo signaling pathway. The present study aimed to investigate the role of ANKHD1 in DU145 and LNCaP prostate cancer cells. ANKHD1 and YAP1 were found to be highly expressed in prostate cancer cells, and ANKHD1 silencing decreased cell growth, delayed cell cycle progression at the S phase, and reduced tumor xenograft growth. Moreover, ANKHD1 knockdown downregulated YAP1 expression and activation, and reduced the expression of CCNA2, a YAP1 target gene. These findings indicate that ANKHD1 is a positive regulator of YAP1 and promotes cell growth and cell cycle progression through Cyclin A upregulation. © 2014 Elsevier Inc.
dc.description324
dc.description2
dc.description137
dc.description145
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dc.languageen
dc.publisherAcademic Press Inc.
dc.relationExperimental Cell Research
dc.rightsfechado
dc.sourceScopus
dc.titleAnkhd1, A Novel Component Of The Hippo Signaling Pathway, Promotes Yap1 Activation And Cell Cycle Progression In Prostate Cancer Cells
dc.typeArtículos de revistas


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