This systematic review without date restrictions is about the physiological effects of conjugated linoleic acid on regression of carcinogenesis, oxidative stress, glucose and lipid metabolism and change in body composition. The objective was to establish the historical aspect of research advances regarding conjugated linoleic acid, considering original articles reporting work on animals, cell cultures and humans. Regarding the researches on the anticarcinogenic effect of conjugated linoleic acid, innumerous evidences were found in this respect, especially in the regression of mammary and colon tumors induced by both isomers which act distinctively. The researchers devoted considerable effort to reinvestigate the antioxidant properties of conjugated linoleic acid. Although the antioxidant properties have been investigated, pro-oxidant effect has been identified leading to oxidative stress in humans. Few studies demonstrated significant beneficial effects of conjugated linoleic acid on the metabolism of lipids and glucose and on the reduction of body fat, especially in humans. Studies with adverse effects were also identified. There is strong indication that the action of this conjugated fatty acid on a class of transition factors - the peroxisome proliferator-activated receptor - and on the consequent modulation of gene expression can be the fundamental explanation of its physiological effects. The most recent studies reinforce the nutrigenomic concept, that is, the modulation of gene expression induced by compounds present in the foods consumed by humans. This current scenario stimulates the scientific community to seek a consensus on the effects of conjugated linoleic acid in humans, since it is naturally found in some foods; when these foods are consumed regularly and in appropriate amounts, they could help prevent and control innumerous chronic diseases.212195221Ha, Y.L., Grimm, N.K., Pariza, M.W., Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid (1987) Carcinogenesis, 8 (12), pp. 1881-1887Wang, Y.M., Jones, P.J.H., Conjugated linoleic acid and obesity control: Efficacy and mechanisms (2004) Int J Obes, 28 (8), pp. 941-955Sisk, M.B., Hausman, D.B., Martin, R.J., Azain, M.J., Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats (2001) J Nutr, 131 (6), pp. 1668-1674Park, Y., Albright, K.J., Liu, W., Storkson, J.M., Cook, M.E., Pariza, M.W., Effect of conjugated linoleic acid on body composition in mice (1997) Lipids, 32 (8), pp. 853-858Botelho, A.P., Santos-Zago, L.F., Reis, S.M.P.M., Oliveira, A.C., A suplementação com ácido linoléico conjugado reduziu a gordura corporal em ratos Wistar. (2005) Rev Nutr, 18 (4), pp. 561-565Ha, Y.L., Storkson, J., Pariza, M.W., Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugad dienoic derivatives of ted linoleic acid (1990) Cancer Res, 50, pp. 1097-1101Flintoff-Dye, N.L., Omaye, S.T., Antioxidant effects of conjugated linoleic acid isomers in isolated human low-density lipoproteins (2005) Nutr Res, 25 (1), pp. 1-12Risérus, U., Vessby, B., Ärnlöv, J., Basu, S., Effects of cis-9, trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men (2004) Am J Clin Nutr, 80 (2), pp. 279-283Smedman, A., Vessby, B., Basu, S., Isomer-specific effects of conjugated linoleic acid on lipid peroxidation in humans: Regulation by α-tocopherol and cyclo-oxygenase-2 inhibitor (2004) Clin Sci, 106 (1), pp. 67-73Pratico, D., Lawson, J.A., Rokach, J., FitzGerald, G.A., The isoprostanes in biology and medicine (2001) Trends Endocrinol Metab, 12 (6), pp. 243-247Basu, S., Smedman, A., Vessby, B., Conjugated linoleic acid induces lipid peroxidation in humans (2000) FEBS Lett, 468 (1), pp. 33-36Yamasaki, M., Mansho, K., Mishima, H., Kimura, G., Sasaki, M., Kasai, M., Effect of dietary conjugated linoleic acid on lipid peroxidation and histological change in rat liver tissues (2000) J Agric Food Chem, 48 (12), pp. 6367-6371Cantwell, H., Devery, R., O'shea, M., Stanton, C., The effect of conjugated linoleic acid on the antioxidant enzyme defense system in rat hepatocytes (1999) Lipids, 34 (8), pp. 833-839Van Den Berg, J.J., Cook, N.E., Tribble, D.L., Reinvestigation of the antioxidant properties of conjugated linoleic acid (1995) Lipids, 30 (7), pp. 599-605Choi, J.S., Song, J., Conjugated linoleic acid, obesity, and insulin resistance: Waiting for the day of liberation from chronic disease (2005) Nutrition, 21 (11-12), pp. 1170-1172Brown, J.M., McIntosh, M.K., Conjugated linoleic acid in humans: Regulation of adiposity and insulin sensitivity (2003) J Nutr, 133 (10), pp. 3041-3046Choi, J.S., Jung, M.H., Park, H.S., Song, J., Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats (2004) Nutrition, 20 (11-12), pp. 1008-1017Nagao, K., Inoue, N., Wang, Y.M., Yanagita, T., Conjugated linoleic acid enhances plasma adiponectin and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats (2003) Biochem Biophys Res Common, 310 (2), pp. 562-566Teachey, M.K., Taylor, Z.C., Maier, T., Saengsirisuwan, V., Sloniger, J.A., Jacob, S., Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat (2003) Metabolism, 52 (9), pp. 1167-1174Chung, S., Brown, J.M., Provo, J.N., Hopkins, R., McIntosh, M.K., Conjugated linoleic acid promotes human adipocyte resistance throught NFkB-dependent cytokine production (2005) J Biol Chem, 280 (46), pp. 38445-38456Roos, B., Rucklidge, G., Reid, M., Ross, K., Duncan, G., Navarro, M.A., Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: A proteomics approach (2005) Faseb J, 29 (29), pp. 1746-1748Hargrave, K.M., Azain, M.J., Kachman, S.D., Miner, J.L., Conjugated linoleic acid does not improve insulin tolerance in mice (2003) Obes Res, 11 (9), pp. 1104-1115Clément, L., Poirier, H., Niot, I., Bocher, V., Guerre-Millo, M., Krief, S., Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse (2002) J Lipid Res, 43 (9), pp. 1400-1409Corl, B.A., Baumgard, L.H., Dwyer, D.A., The role of delta-9-desaturase in the production of cis-9, trans-11 (2001) J Nutr Biochem, 12 (11), pp. 622-630Martin, S.A., Jenkins, T.C., Factors affecting conjugated linoleic acid trans-C18:1 fatty acid production by mixed ruminal bacteria (2002) J Anim Sci, 80 (12), pp. 3347-3352Alonso, L., Cuesta, E.P., Gilliland, S.E., Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin (2003) J Dairy Sci, 86 (6), pp. 1941-1946Griinari, J.M., Corl, B.A., Lacy, S.H., Chouinard, P.Y., Nurmela, K.V., Bauman, D.E., Conjugated linoleic acid is synthesized endogenously in lacting dairy cows by Δ9 desaturase (2000) J Nutr, 130 (9), pp. 2285-2291Park, Y., Storkson, J.M., Ntambi, J.M., Cook, M.E., Sih, C.J., Pariza, M.W., Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives (2000) Biochim Biophys Acta, 1486 (2-3), pp. 285-292Pariza, M.W., Park, Y., Cook, M.E., The biologically active isomers of conjugated linoleic acid (2001) Prog Lipid Res, 40 (4), pp. 283-298Christie, W.W., A simple procedure for rapid transmethylation of glycerolipids and cholesteryl esters (1982) J Lipid Res, 23 (7), pp. 1072-1075Chin, S.F., Liu, W., Storkson, J.M., Ha, Y.L., Pariza, M.W., Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens (1992) J Food Compos Anal, 5, pp. 185-197Ritzenthaler, K.L., McGuire, M.K., Falen, R., Shultz, T.D., Dasgupta, N., McGuire, M.A., Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology (2001) J Nutr, 131 (5), pp. 1548-1554Jiang, J., Wolk, A., Vessby, B., Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue (1999) Am J Clin Nutr, 70 (1), pp. 21-27Fritsche, J., Steinhart, H., Amounts of conjugated linoleic acid (CLA) in German foods and evaluation of daily intake (1998) Eur Food Res Technol, 206, pp. 77-82(2002) Dietary reference intakes for energy, carbohydrates, fiber, fat, fatty acids, cholesterol, protein and amino acids, , National Academy of Sciences (USA, Washington DC, National Academy Press;Ha, Y.L., Grimm, N.K., Pariza, M.W., Newly recognized anticarcinogenic fatty acid: Identification and quantification in natural and processed cheeses (1989) J Agric Food Chem, 37, pp. 75-81Ip, C., Chin, S.F., Scimeca, J.A., Pariza, M.W., Mammary cancer prevention by conjugated dienoic derivative of linoleic acid (1991) Cancer Res, 51 (22), pp. 6118-6124Chujo, H., Yamasaki, M., Nou, S., Koyanagi, N., Tachibana, H., Yamada, K., Effect of conjugated linoleic acid isomers on growth factor-induced proliferation of human breast cancer cells (2003) Cancer Lett, 202 (1), pp. 81-87Masso-Welch, P.A., Zangani, D., Ip, C., Vaughan, M.M., Shoemaker, S.F., McGee, S.O., Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature (2004) J Nutr, 134 (2), pp. 299-307Tanmahasamut, P., Liu, J., Hendry, L.B., Sidell, N., Conjugated linoleic acid blocks estrogen signaling in human breast cancer cells (2004) J Nutr, 134 (3), pp. 674-680Liu, J., Sidell, N., Anti-estrogenic effect of conjugated linoleic acid through modulation of estrogen receptor phosphorylation (2005) Breast Cancer Res Tr, 94, pp. 161-169Albright, C.D., Klem, E., Shah, A.A., Gallagher, P., Breast cancer cell-targeted oxidative stress: Enhancement of cancer cell uptake of conjugated linoleic acid, activation of p53, and inhibition of proliferation (2005) Exp Mol Pathol, 79 (2), pp. 118-125Miglietta, A., Bozzo, F., Bocca, C., Gabriel, L., Trombetta, A., Belotti, S., Canuto, R.A., Conjugated linoleic acid induces apoptosis in MDA-MB-231 breast cancer cells through ERK/MAPK signaling and mitochondrial pathway (2006) Cancer Lett, 234 (2), pp. 149-157Kim, J.H., Hubbard, N.E., Ziboh, V., Erickson, K.L., Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein (2005) Biochim Biophys Acta, 1736 (3), pp. 244-250Degner, S.C., Kemp, M.K., Bowden, G.T., Romagnolo, D.F., Conjugated linoleic acid attenuates cyclooxygenase-2 transcriptional activity via an anti-AP-1 mechanism in MCF-7 breast cancer cells (2006) J Nutr, 136 (2), pp. 421-427Liew, C., Shut, H.A.J., Chin, S.F., Pariza, M.W., Dashwood, R.H., Protection of conjugated linoleic acids against 2-amino-3-methylimidazol[4,5-f]quinolin- induced colon carcinogenesis in the F344 rat: A study of inhibitory mechanisms (1995) Carcinogenesis, 16, pp. 3037-3043O'Shea, M., Stanton, C., Devery, R., Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid (1999) Anticancer Res, 19 (3 A), pp. 1953-1960Park, H.S., Ryu, J.H., Ha, Y.L., Park, Y., Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: A possible mechanism of the anticarcinogenic effect by CLA (2001) Brit J Nutr, 86, pp. 549-555Park, H.S., Cho, H.Y., Ha, Y.L., Park, J.H.Y., Dietary conjugated linoleic acid increases the mRNA ratio of Bax/Bcl-2 in the colonic mucosa of rats (2004) J Nutr Biochem, 15 (4), pp. 229-235Lim, D.Y., Tyner, A.L., Park, J.B., Lee, J.Y., Choi, Y.H., Park, J.H.Y., Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1 (2005) J Cell Physiol, 205 (1), pp. 107-113Cho, H.J., Kim, E.J., Lim, S.S., Kim, M.K., Sung, M.K., Kim, J.S., Trans-10, cis-12, not cis-9, trans-11, conjugated linoleic acid inhibits G1-S progresión in HT-29 human colon cancer cells (2006) J Nutr, 136, pp. 893-898Lee, S.H., Yamaguchi, K., Kim, J.S., Eling, T.E., Safe, S., Park, Y., Conjugated linoleic acid stimulates an antitumorigenic protein NAG-1 in an isomer specific manner (2006) Carcinogenesis, 27 (5), pp. 972-981Ip, C., Briggs, S.P., Haegele, A.D., Thompson, H.J., Storkson, J., Scimeca, J.A., The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet (1996) Carcinogenesis, 17 (5), pp. 1045-1050Hubbard, N.E., Lim, D., Erickson, K.L., Beef Tallow increases the potency of conjugated linoleic acid in the reduction of mouse mammary tumor metatastasis (2006) J Nutr, 136 (1), pp. 88-93Agatha, G., Voigt, A., Kauf, E., Zintl, F., Conjugated linoleic acid modulation of cell membrane in leukemia cells (2004) Cancer Lett, 209 (1), pp. 87-103Ochoa, J., Farquharson, A.J., Grant, I., Moffat, L.E., Heys, S.D., Wahle, W.J., Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: Different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers (2004) Carcinogenesis, 25 (7), pp. 1185-1191Lui, O.A., Mak, N.K., Leung, K.N., Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells (2005) Int J Oncol, 27 (6), pp. 1737-1743Song, H.J., Sneddon, A.A., Heys, S.D., Wahle, K.W.J., Induction of apoptosis and inhibition of NF-κB activation in human prostate cancer cells by the cis-9, trans-11 but not the trans-10, cis-12 isomer of conjugated linoleic acid (2006) Prostate, 66, pp. 839-846Kuniyasu, H.K., Yoshida, K., Sasaki, T., Sasahira, T., Fujii, K., Ohmori, H., Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells (2006) Int J Cancer, 118 (3), pp. 571-576Yang, L., Leung, L.K., Huang, Y., Chen, Z.Y., Oxidative stability of conjugated linoleic acid isomers (2000) J Agric Food Chem, 48 (8), pp. 3072-3076Tsuzuki, T., Igarashi, M., Iwata, T., Ymauchi-Sato, Y., Yamamoto, T., Ogita, K., Oxidation rate of conjugated linoleic acid and conjugated linolenic acid is slowed by triacylglycerol esterification and α-tocopherol (2004) Lipids, 39 (5), pp. 475-480Miyazawa, T., Tsuzuki, T., Nakagawa, K., Igarashi, M., Fatty acids with conjugated unsaturation: Relationship between oxidative stability and physiological activities (2005) Lipid Technol, 17, pp. 221-225Santos-Zago, L.F., Botelho, A.P., Reis, S.M.P.M., Oliveira, A.C., Isomers characterization and autoxidation stability of two conjugated linoleic acid (CLA) supplements (2006) Annals of the 4th Euro Fed Lipid Congress, , OctMadrid, Spain;, Abstract LAMI-001.aBasu, S., Risérus, U., Turpein, A., Vessby, B., Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity (2000) Clin Sci, 99 (6), pp. 511-516Risérus, U., Basu, S., Jovinge, S., Fredrikson, G.N., Ärnlöv, J., Vessby, B., Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein (2002) Circulation, 106 (15), pp. 1925-199aArab, K., Rossary, A., Soulère, L., Steghens, J.P., Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation (2006) Brit J Nutr, 96 (5), pp. 811-819Santos-Zago, L.F., Botelho, A.P., Reis, S.M.P.M., Oliveira, A.C., Consumo de CLA tem correlação negativa com indicadores da oxidação lipídica (2006) Anais do 14° Congresso Latinoamericano de Nutrição, , novFlorianópolis, Brasil;, Abstract NE 0020.bLee, K.N., Kritchevsky, D., Pariza, M.W., Conjugated linoleic acid and atherosclerosis in rabbits (1994) Atherosclerosis, 108 (1), pp. 19-25Deckere, E.A.M., Amelsvoort, J.M.M.V., Mcneill, G.P., Jones, P., Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster (1999) Br J Nutr, 82 (4), pp. 309-317Munday, J.S., Thompson, K.G., James, K.A., Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model (1999) Br J Nutr, 81 (3), pp. 251-255Corino, C., Mourot, J., Magni, S., Pastorelli, G., Rosi, F., Influence of dietary linoleic acid in growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits (2002) J Anim Sci, 80 (4), pp. 102-108Mitchell, P.L., Langille, M.A., Currie, D.L., McLeod, R.S., Effect of conjugated linoleic acid isomers on lipoproteins and atherosclerosis in the Syrian Golden hamster (2005) Biochim Biophys, 1734 (3), pp. 269-276Valeille, K., Ferezou, J., Amsler, G., Quignard-Boulange, A., Parquet, M., Gripois, D., A cis-9, trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster (2005) Am J Physiol Heart Circ Physiol, 289, pp. 652-659Benito, P., Nelson, G.J., Kelly, D.S., Bartolini, G., Schimidt, P.C., Simon, V., The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans (2001) Lipids, 36 (3), pp. 229-236Mougious, V., Matsakas, A., Petridou, A., Ring, S., Sagredos, A., Melissopoulou, A., Effect of supplementation with conjugated linoleic acid in human serum lipids and body fat (2001) J Nutr Biochem, 12 (10), pp. 585-594Petridou, A., Mougious, V., Sagredos, A., Supplementation with CLA: Isomer incorporation into serum and effect on body fat of women (2003) Lipids, 38 (8), pp. 805-811Gaullier, J.M., Halse, J., Hoye, K., Kristiansen, K., Fagertun, H., Vik, H., Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans (2004) Am J Clin Nutr, 79 (6), pp. 1118-1125Whigham, L.D., O'Shea, M., Mohede, I.C.M., Walaski, H.P., Atkinson, R.L., Safety profile of conjugated linoleic acid in a 12-month trial in obese humans (2004) Food Chem Toxicol, 42 (10), pp. 1701-1709Smedman, A., Vessby, B., Conjugated linoleic acid supplementation in humans-metabolic effects (2001) Lipids, 36 (8), pp. 773-781Tricon, S., Burdge, G.C., Kew, S., Banerjee, T., Russel, J.J., Jones, E.L., Opposing effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid on blood lipids in healthy humans (2004) Am J Clin Nutr, 80 (3), pp. 614-620Bissonauth, V., Chouinard, Y., Marin, J., Leblanc, N., Richard, D., Jacques, H., The effects of t10, c12 CLA isomer compared with c9, t11 CLA isomer on lipid metabolism and body composition in hamsters (2006) J Nutr Biochem, 17 (9), pp. 597-603Belury, M., Moya-Camarena, S.Y., Liu, K.L., Vanden Heuvel, J.P., Dietary conjugated linoleic acid induces peroxisome-specif enzyme accumulation and ornithine decarboxylase activity in mouse liver (1997) J Nutr Biochem, 8, pp. 579-584Sakono, M., Miyanaga, F., Kawahara, S., Yamauchi, K., Fukuda, N., Watanable, K., Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver (1999) Lipids, 34 (9), pp. 997-1000Martin, J.C., Grégoire, S., Siess, M.H., Genty, M., Chardigny, J.M., Berdeaux, O., Effects of conjugated linoleic acid isomers on lipid-metabolizing enzymes in male rats (2000) Lipids, 35 (1), pp. 91-98Sergiel, J.P., Chardigny, J.M., Sébédio, J.L., Berdeaux, O., Juanéda, P., Loreau, O., β-oxidation of conjugated linoleic acid isomers and linoleic acid in rats (2001) Lipids, 36 (12), pp. 1327-1329Macarulla, M.T., Fernandez-Quintela, A., Zabala, A., Navarro, V., Echevarria, E., Churruca, I., Effects of conjugated linoleic acid on liver composition and fatty acid oxidation are isomer-dependent in hamster (2005) Nutrition, 21 (4), pp. 521-619Zabala, A., Fernández-Quintela, A., Macarulla, T., Simón, E., Rodríguez, V.M., Navarro, V., Effects of conjugated linoleic acid on skeletal muscle triacylglycerol metabolism in hamsters (2006) Nutrition, 22 (5), pp. 528-533Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H., Tange, T., Okuyama, H., Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice (2000) Diabetes, 49 (9), pp. 1534-1542Clément, L., Poirier, H., Niot, I., Bocher, V., Guerremillo, M., Krief, S., Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse (2002) J Lipid Res, 43 (9), pp. 1400-1409Risérus, U.M., Arner, P., Brismar, K., Vessby, B., Treatment with dietary trans10, cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome (2002) Diabetes Care, 25 (9), pp. 1516-121bHouseknecht, K.L., Vanden Heuvel, J.P., Moya-Camarena, S.Y., Portocarrero, C.P., Peck, L.W., Nickel, K.P., Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat (1998) Biochem Biophys Res Commun, 244 (3), pp. 911-917Simon, E., Macarulla, M.T., Churruca, I., Fernandez-Quintela, A., Portillo, M.P., Trans-10, cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by na atherogenic diet in hamsters (2006) J Nutr Biochem, 17 (2), pp. 126-131Poirier, H., Rouault, C., Clément, L., Niot, I., Monnot, M.C., Guerre-Millo, M., Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in themaouse (2005) Diabetologia, 48, pp. 1059-1065Belury, M., Mahon, A., Banni, S., The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus (2003) J Nutr, 133 (1), pp. 257-260Moloney, F., Yeow, T.P., Mullen, A., Nolan, J.J., Roche, H.M., Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus (2004) Am J Clin Nutr, 80 (4), pp. 887-895Taylor, J.S.W., Williams, R.R., James, P., Frenneaux, M.P., Conjugated linoleic acid impairs endothelial function (2006) Arterioscl Throm Vas, 26 (2), pp. 307-312Park, Y., Storkson, J.M., Ntambi, J.M., Cook, M.E., Sih, C.J., Pariza, M.W., Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid indues body composition changes in mice (1999) Lipids, 34 (3), pp. 235-241Ostrowska, E., Muralitharan, M., Cross, R.F., Bauman, D.E., Dunshea, F.R., Dietary conjugated acid increases lean tissue and decreases fat deposition in growing pigs (1999) J Nutr, 129, pp. 2037-2042Zambell, K.L., Keim, N.L., Van Loan, M.D., Gale, B., Benito, P., Kelley, D.S., Conjugated linoleic acid supplementation in humans: Effects on body composition and energy expenditure (2000) Lipids, 35 (7), pp. 777-782Blankson, H., Stakkestad, J.Á., Fagertun, H., Thom, E., Wadstein, J., Gudmundsen, O., Conjugated linoleic acid reduces body fat mass in overweight and obese humans (2000) J Nutr, 130 (12), pp. 2943-2948Berven, G., Bye, A., Hals, O., Blankson, H., Fagertun, H., Thom, E., Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers (2000) Eur J Lipid Sci Technol, 102, pp. 455-462Azain, M.J., Hausman, D.B., Sisk, M.B., Flatt, W.P., Jewell, D.E., Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J Nutr (2000), 130 (6). , 15-48, 54Poulos, S.P., Sisk, M., Hausman, D.B., Azain, M.J., Hausman, G.J., Pre and postnatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague-Dawley rats (2001) J Nutr, 131 (10), pp. 2722-2731Takahashi, Y., Kushiro, M., Shinohara, K., Ide, T., Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice (2002) Comp Biochem Phys, 133 (3), pp. 395-404Pariza, M.W., Park, Y., Cook, M.E., Mechanisms of action of conjugated linoleic acid: Evidence and speculation (2000) Proc Soc Exp Biol Med, 223 (1), pp. 8-13Evans, M., Geigerman, C., Cook, J., Curtis, L., Kuebler, B., McIntosh, M., Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosos in 3T3-L1 preadipocytes (2000) Lipids, 35 (8), pp. 899-910McNeel, R.L., Mersmann, H.J., Conjugated linoleic acid isomers influence porcine adipocyte differentiation in vitro (2001) Faseb J, 15, p. 996Brown, M., Evans, M., McIntosh, M., Linoleic acid partially restores the triglyceride content of conjugated linoleic acid-treated cultures of 3T3-L1 preadipocytes (2001) J Nutr Biochem, 12 (7), pp. 381-387Kang, K., Liu, W., Albright, K.J., Park, Y., Pariza, M.W., Trans-10, cis-12 inhibits differentiation of 3T3-L1 adipocytes and decrases PPAR gamma expression (2003) Biochem Bioph Res Co, 303 (3), pp. 795-799Thom, E., Wadstein, J., Gudmundsen, O., Conjugated linoleic acid reduces body fat in healthy exercising humans (2001) Med Res, 29 (5), pp. 392-396Kreider, R.B., Ferreira, M.P., Greenwood, M., Wilson, M., Almada, A.L., Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers (2002) J Strength Cond Res, 16 (3), pp. 325-334Noone, E., Roche, H., Nugent, A., Gibney, M., The effect of dietary suppleemntation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects (2002) Br J Nutr, 88 (3), pp. 243-251Kamphuis, M., Lejeune, M., Saris, M., Westertep-Plantega, W., The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subject (2003) Int J Obes Relat Metabol Disord, 25, pp. 1516-1521Malpuech-Brugère, C., Wilhelmine, P.H.G., Verboeket-van, V., Mensink, R.P., Arnal, M.A., Morio, B., Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans (2004) Obes Res, 12 (4), pp. 591-598Gaullier, J.M., Halse, J., Hoye, K., Kristiansen, K., Fagertun, H., Vik, H., Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans (2005) J Nutr, 135 (4), pp. 778-784Desroches, S., Chouinard, P.Y., Galibois, I., Corneau, L., Delisle, J., Lamarche, B., Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men (2005) Am J Clin Nutr, 82 (2), pp. 309-319Brodie, A.E., Manning, V.A., Ferguson, K.R., Jewell, D.E., Hu, C.Y., Conjugated linoleic acid inhibits differentiation of pre- and post- confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells (1999) J Nutr, 129 (3), pp. 602-606Choi, Y.J., Kim, Y.C., Han, Y.B., Park, Y., Pariza, M.W., Ntambi, J.M., The trans-10, cis-12 isomer of conjugated linoleic acid downregulated stearoyl-CoA desaturase gene expression in 3T3-L1 adipocytes (2000) J Nutrition, 130, pp. 1920-1924Rahman, S.M., Wang, Y.M., Yotsumoto, H., Cha, J.Y., Han, S.Y., Inoue, S., Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats (2001) Nutrition, 17 (5), pp. 385-390Evans, M.E., Brown, J.M., McIntosh, M.K., Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism (2002) J Nutr Biochem, 13 (9), pp. 508-516West DB, Delany JP, Camet PM, Blohm F, Truett AA, Scimeca J. Effects of conjugated linoleic acid on body composition fat and energy metabolism in the mouse. Am J Physiol. 1998275(3PT2):667-72Ryder, J.W., Portocarrero, C.P., Song, X.M., Cui, L., Yu, M., Combatsiaris, Y., Isomer-specific antidiabetic properties of conjugated linoleic acid improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression (2001) Diabetes, 50, pp. 1149-1157Terpstra, A.H.M., Beynen, A.C., Everts, H., Kocsis, S., Katan, M.B., Zock, P.L., The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta (2002) J Nutr, 132 (5), pp. 940-945Zhang, B., Graziano, M.P., Doebber, T.W., Leibowitz, M.D., White-Carrington, S., Szalkowshi, D.M., Down-regulation of the expression of the obese gene by an antidiabetic thoazolidinedione in Zucker diabetic fatty rats and db/db mice (1996) J Biol Chem, 271 (16), pp. 9455-9459Yamasaki, M., Ikeda, A., Oji, M., Tanaka, O., Hirao, A., Kasai, M., Modulation of body fat and serum leptin levels by dietary linoleic acid in Sprague-Dawley rats fed various fat-level diets (2003) Nutrition, 19 (1), pp. 30-35Medina, E.A., Horn, W.F., Keim, N.L., Havel, P.J., Benito, P., Kelly, D.S., Conjugated linoleic acid supplementation in humans: Effects on circulating leptin concentrations and appetite (2000) Lipids, 35 (7), pp. 783-788Botelho, A.P., Santos-Zago, L.F., Reis, S.M.P.M., Oliveira, A.C., Correlaç ão entre a gordura corporal e os teores séricos de leptina de ratos wistar suplementados com ácido linoléico conjugado (2005) Anais do 8° Congresso Nacional da Sociedade Brasileira de Alimentação e Nutrição, , São Paulo, Brasil;, Abstract PO-16-172Botelho AP, Santos-Zago LF, Reis SMPM, Oliveira AC. Ácido linoléico conjugado reduz a atividade da lípase lipoprotéica. Anais do 14° Congresso Latinoamericano de Nutrição2006 novFlorianópolis, Brasil2006. Abstract NE 0099Issemann, I., Green, S., Activation of a member of steroid hormone receptor superfamily by peroxisome proliferators (1990) Nature, 347 (6294), pp. 645-650Atarod, E.B., Kehrer, J.P., Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines (2004) Free Radical Bio Med, 37, pp. 36-47Gottlicher, M., Widmark, E., Li, Q., Gustafsson, J.A., Fatty acid activate a chimeric of the clofibric acid-activated receptor and the glucocorticoid receptor (1992) P Natl Acad Sci USA, 89 (10), pp. 4653-4657Moya-Camarena, S.Y., Vanden Heuvel, J.P., Blanchard, S.G., Leesnitzer, L.A., Belury, M.A., Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα (1999) J Lipid Res, 40 (8), pp. 1426-1433Moya-Camarena, S., Vanden Heuvel, J.P., Conjugated linoleic acid activates peroxisome proliferator-activated receptor a and b subtypes but does not induce hepatic peroxisome proliferation in Spragu-Dawley rats (1999) Biochim Bioph Acta, 1436 (3), pp. 331-342Lampen, A., Leifheit, M., Voss, J., Nau, H., Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: Effects on proliferation, differentiation, and gene expression (2005) Biochim Bioph Acta, 1735 (1), pp. 30-40Cimini, A.M., Cristiano, L., Colafarina, S., Benedetti, E., Di Loreto, S., Festuccia, C., PPARg-dependent effects of conjugated linoleic acido in the human glioblastoma cell line (ADF) (2005) Int J Cancer, 117, pp. 923-933Evans, M., Park, Y., Pariza, M., Curtis, L., Kuebler, B., McIntosh, M., Trans-10, cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor γ2 and aP2 expression in 3T3-L1 preadipocytes (2001) Lipids, 36 (11), pp. 1223-1232Granlund, L., Juvet, L.K., Pedersen, J.I., Trans10, cis12- conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPAR? modulator (2003) J Lipid Res, 44, pp. 1441-1452Brown, J.M., Boysen, M.S., Jensen, S.S., Morrison, R.F., Storkson, J., Lea-Currie, R., Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes (2003) J Lipid Res, 44, pp. 1287-1300Bassaganya-Riera, J., Reynolds, K., Martino-Catt, S., Cui, Y., Hennighausen, L., Gonzalez, F., Acyivation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease (2004) Gastroenterology, 127 (3), pp. 777-791Ringseis, R., Müller, A., Herter, C., Gahler, S., Steinhart, H., Eder, K., CLA isomers inhibit TNFα-induced eicosanoid release from human vascular smooth muscle cells via a PPARγ ligand-like action (2006) Biochim Bioph Acta, 1760, pp. 290-300Bassaganya-Riera, J., Hontecillas, R., CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD (2006) Clin Nutr, 25 (3), pp. 454-465Kelley, D.S., Taylor, P.C., Nelson, G.J., Schmidt, P.C., Ferretti, A., Erickson, K.L., Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men (1999) Lipids, 34 (4), pp. 317-324Kew, S., Gibbons, E.S., Thies, F., McNeill, G.P., Quinlan, P.T., Calder, P.C., The effect of feeding structured triacylglycerols enriched in eicosapentaenoic or docosahexaenoic acids on murine splenocyte fatty acid composition and leucocyte phagocytosis (2003) Br J Nutr, 90 (6), pp. 1071-1080Benjamin, S., Hanhoff, T., Börchers, T., Spener, F., An improved molecular test system for the screening of human PPAR transactivation by conjugated linoleic acid isomers and their precursor fatty acids (2005) Eur J Lipid Sci, 107, pp. 706-715Larsen, T.M., Toubro, S., Gudmundsen, O., Astrup, A., Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain (2006) Am J Clin Nutr, 83 (3), p. 606