Artículos de revistas
Control Of Allantoin Accumulation In Comfrey
Natural Product Communications. , v. 3, n. 9, p. 1411 - 1422, 2008.
Comfrey, a medicinal herb with healing properties that are attributed to allantoin, was studied in this work. The accumulation and metabolism of allantoin (ALN) and its degradation product, allantoic acid (ALA), were examined. ALN was the main ureide in leaves and roots, with young leaves showing the highest content. ALA was the predominant ureide in the xylem sap, and together with ALN represented 27% of the nitrogen (N) transported in the xylem. Amino acids were the most abundant Ncompound in the xylem sap with a high proportion of glutamine. [ 14C]Xanthine feeding experiments showed that ALN and ALA were actively formed in leaves and roots by degradation of xanthine. Both xanthine and uric acid were rapidly degraded to form ALN and ALA. Enzyme studies showed that calculated V max/K m are low for allantoinase and alantoicase, supporting the results from the feeding experiments, and indicating that accumulation of ALN in comfrey is due to a low capacity for the enzymatic degradation of ureides.3914111422Schubert, K.R., Boland, M.J., The ureides (1990) Intermediary Nitrogen Metabolism, pp. 197-282. , Miflin BJ, Lea PJ. (Eds), Academic Press, New YorkSchubert, K.R., Products of biological nitogen fixation in higher plants: Synthesis, transport, and metabolism (1986) Annual Review of Plant Physiology, 37, pp. 539-574Mosquim, P.R., Sodek, L., Partitioning of nitrogen in soybean fruit explants cultured with glutamine, asparagine or allantoin (1992) Plant Physiology and Biochemistry, 30, pp. 451-457Pate, J.S., Atkins, C.A., Hamel, K., McNeil, D.L., Layzell, D.B., Transport of organic solutes in phloem and xylem of a nodulated legume (1979) Plant Physiology, 63, pp. 1082-1088Polayes, D.A., Schubert, K.R., Purine synthesis and catabolism in soybean seedlings. The biogenesis of ureides (1984) Plant Physiology, 75, pp. 1104-1110Tajima, S., Nomura, M., Kouchi, H., Ureide biosynthesis in legume nodules (2004) Frontiers in Bioscience, 9, pp. 1374-1381Schwarz, G., Mendel, R.R., Molybdenum cofactor biosynthesis and molybdenum enzymes (2006) Annual Review of Plant Biology, 57, pp. 623-647Sarma, A.D., Serfozo, P., Kahn, K., Tipton, P.A., Identification and purification of hydroxyisourate hydrolase, a novel ureide-metabolizing enzyme (1999) Journal of Biological Chemistry, 274 (48), pp. 33863-33865Kahn, K., Serfozo, P., Tipton, P.A., Identification of the true product of the urate oxidase reaction (1997) Journal of the American Chemical Society, 119 (23), pp. 5435-5442. , DOI 10.1021/ja970375tTodd, C.D., Polacco, J.C., Soybean cultivars 'Williams 82" and "Maple Arrow" produce both urea and ammonia during ureide degradation (2004) Journal of Experimental Botany, 398, pp. 867-877Vadez, V., Sinclair, T.R., Ureide degradation pathways in intact soybean leaves (2000) Journal of Experimental Botany, 51 (349), pp. 1459-1465Piedras, P., Pineda, M., Manganese is essential for activity of allantoate amidinohydrolase from Chlamydomonas reinhardtii (2003) Plant Science, 165 (2), pp. 423-428. , DOI 10.1016/S0168-9452(03)00203-6Muñoz, A., Piedras, P., Aguilar, M., Pineda, M., Urea is a product of ureidoglycolate degradation in chickpea. Purification and characterization of the ureidoglycolate urea-lyase (2001) Plant Physiology, 125, pp. 828-834Munoz, A., Raso, M.J., Pineda, M., Piedras, P., Degradation of ureidoglycolate in French bean (Phaseolus vulgaris) is catalysed by a ubiquitous ureidoglycolate urea-lyase (2006) Planta, 224 (1), pp. 175-184. , DOI 10.1007/s00425-005-0186-8Todd, C.D., Tipton, P.A., Blevins, D.G., Piedras, P., Pineda, M., Polacco, J.C., Update on ureide degradation in legumes (2006) Journal of Experimental Botany, 57, pp. 5-12Thomas, R.J., Schrader, L.E., Ureide metabolism in higher plants (1981) Phytochemistry, 20, pp. 361-371Dobereiner, J., Biological nitrogen fixation in the tropics: Social and economic contributions (1997) Soil Biology and Biochemistry, 29, pp. 771-774Cheng, X.G., Nomura, M., Takane, K., Kouchi, H., Tajima, S., Expression of two uricase (Nodulin-35) genes in a non-ureide type legume, Medicago sativa (2000) Plant Cell Physiology, 41, pp. 104-109Yesbergenova, Z., Yang, G., Oron, E., Soffer, D., Fluhr, R., Sagi, M., The plant Mo-hydroxylases aldehyde oxidase and xanthine dehydrogenase have distinct reactive oxygen species signatures and are induced by drought and abscisic acid (2005) Plant Journal, 42 (6), pp. 862-876. , DOI 10.1111/j.1365-313X.2005.02422.xYang, J., Han, K.-H., Functional characterization of allantoinase genes from Arabidopsis and a nonureide-type legume black locust (2004) Plant Physiology, 134 (3), pp. 1039-1049. , DOI 10.1104/pp.103.034637Desimone, M., Catoni, E., Ludewig, U., Hilpert, M., Schneider, A., Kunze, R., Tegeder, M., Schumacher, K., A novel superfamily of transporters for allantoin and other oxo derivatives of nitrogen heterocyclic compounds in Arabidopsis (2002) Plant Cell, 14, pp. 847-856Stahlhut, R.W., Widholm, J.M., Ureide catabolism by soybean [Glycine max (L.) Merril] cell suspension cultures II: Assimilation of allantoin (1989) Journal of Plant Physiology, 134, pp. 90-97Filippi, S.B., Azevedo, R.A., Sodek, L., Mazzafera, P., Allantoin has a limited role as nitrogen source in cultured coffee cells (2007) Journal of Plant Physiology, 164, pp. 544-552Bollard, E.G., Nitrogenous compounds in tracheal sap of woody members of the family Rosaceae (1957) Australian Journal of Biological Science, 10, pp. 288-291Bollard, E.G., Translocation of organic nitrogen in the xylem (1957) Australian Journal of Biological Science, 10, pp. 292-301Bollard, E.G., Composition of the nitrogen fraction of apple tracheal sap (1957) Australian Journal of Biological Science, 10, pp. 279-287Osuji, G.O., Ory, R.L., Regulation of allantoin and alantoic acid degradation in the yam and sweet potato (1987) Journal of Agricultural and Food Chemistry, 35, pp. 219-223Piedras, P., Aguilar, M., Pineda, M., Uptake and metabolism of allantoin and allantoate by cells of Chlamydomonas reinhardtii (Chlorophyceae) (1998) European Journal of Phycology, 33, pp. 57-64Rode, D., Comfrey toxicity revisited (2002) Trends in Pharmacological Science, 23, pp. 497-499Sousa, M.P., Matos, M.E.O., Matos, F.J.A., Machado, M.I.L., Craveiro, A.A., (1991) Constituintes Químicos Ativos de Plantas Medicinais Brasileiras, , Editora da Universidade Federal do Ceará, Fortaleza, BrazilChen, X.B., Determination of allantoin in biological, cosmetic, and pharmaceutical samples (1996) Journal of AOAC International, 79, pp. 628-635Thornfeldt, C., Cosmeceuticals containing herbs: Fact, fiction, and future (2005) Dermatologic Surgery, 31, pp. 873-880Mothes, K., The metabolism of urea and ureides (1961) Canadian Journal of Botany, 39, pp. 1785-1807Teixeira, J.P.F., Duarte, F.R., Avaliação do teor de ureídeos em plantas de confrei (1985) Bragantia, 44, pp. 487-492Thomas, R.J., Feller, U., Erismann, K.H., Ureide metabolism in non-nodulated Phaseolus vulgaris L (1980) Journal of Experimental Botany, 31, pp. 409-417Amarante, L., Sodek, L., Growth and stress conditions cause similar changes in xylem amino acids for different legume species (2006) Environmental and Experimental Botany, 58, pp. 123-129Herridge, D.F., Atkins, C.A., Pate, J.S., Rainbird, R.M., Allantoin and allantoic acid in the nitrogen economy of the cowpea [Vigna unguiculata (L.) Walp.] (1978) Plant Physiology, 62, pp. 495-498McClure, P.R., Israel, D.W., Transport of nitrogen in the xylem of soybean plants (1979) Plant Physiology, 64, pp. 411-416Lima, J.D., Sodek, L., N-stress alters aspartate and asparagine levels of xylem sap in soybean (2003) Plant Science, 165, pp. 649-656Smith, P.M.C., Atkins, C.A., Purine biosynthesis. Big in cell division, even bigger in nitrogen assimilation (2002) Plant Physiology, 128, pp. 793-802Ashihara, H., Monteiro, A.M., Moritz, T., Gillies, F.M., Crozier, A., Catabolism of caffeine and related purine alkaloids in leaves of Coffea arabica L (1996) Planta, 198, pp. 334-339Vitória, A.P., Mazzafera, P., Xanthine degradation and related enzymes activities in leaves and fruits of two Coffea species differing in caffeine catabolism (1999) Journal of Agricultural and Food Chemistry, 47, pp. 1851-1855Nishino, T., Okamoto, K., Kawaguchi, Y., Hori, H., Matsumura, T., Eger, B.T., Pai, E.F., Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase - Identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant (2005) Journal of Biological Chemistry, 280, pp. 24888-24894Sauer, P., Frébort, I., Molybdenum cofactor-containing oxidoreductase family in plants (2003) Biologia Plantarum, 46, pp. 481-490Mazzafera, P., Catabolism of caffeine in plants and microorganisms (2004) Frontiers in Bioscience, 9, pp. 1348-1359Sauer, P., Frebortova, J., Sebela, M., Galuszka, P., Jacobsen, S., Pec, P., Frebort, I., Xanthine dehydrogenase of pea seedlings: A member of the plant molybdenum oxidoreductase family (2002) Plant Physiology and Biochemistry, 40, pp. 393-400Mendel, R.R., Molybdenum cofactor of higher plants: Biosynthesis and molecular biology (1997) Planta, 203, pp. 399-405Boland, M.J., Blevins, D.G., Randall, D.D., Soybean nodule xanthine dehydrogenase: A kinetic study (1983) Archives of Biochemistry and Biophysics, 222, pp. 435-441Nguyen, J., Plant xanthine dehydrogenase - Its distribution, properties and function (1986) Physiologie Vegétale, 24, pp. 263-281Tajima, S., Yamamoto, Y., Enzymes of purine catabolism in soybean plants (1975) Plant and Cell Physiology, 16, pp. 271-282Montalbini, P., Aguilar, M., Pineda, M., Isolation and characterization of uricase from bean leaves and its comparison with uredospore enzymes (1999) Plant Science, 147, pp. 139-147Montalbini, P., Redondo, J., Caballero, J.L., Cárdenas, J., Pineda, M., Uricase from leaves: Its purification and characterization from three different higher plants (1997) Planta, 202, pp. 277-283Lucas, K., Boland, M.J., Schubert, K.R., Uricase from soybean root nodules: Purification, properties and comparison with the enzyme from cowpea (1983) Archives of Biochemistry and Biophysics, 226, pp. 190-197Bergmann, H., Preddie, E., Verna, D.P.S., Nodulin-35: A subunit of specific uricase (uricase II) induced and localized in the uninfected cell of soybean nodules (1983) EMBO Journal, 12, pp. 2333-2339Rainbird, M.R., Atkins, C., Purification and some properties of urate oxidase from nitrogen-fixing nodules of cowpea (1981) Biochimica and Biophysica Acta, 659, pp. 132-140Bell, J.A., Webb, M.A., Immunoaffinity purification and comparison of allantoinases from soybean root nodules and cotyledons (1995) Plant Physiology, 107, pp. 435-441Webb, M.A., Lindell, J.S., Purification of allantoinase from soybean seeds and production and characterization of antiallantoinase antibodies (1993) Plant Physiology, 103, pp. 1235-1241Raso, M.J., Pineda, M., Piedras, P., Tissue abundance and characterization of two purified proteins with allantoinase activity from French bean (Phaseolus vulgaris) (2007) Physiologia Plantarum, 131, pp. 355-366Mary, A., Nirmala, J., Sastry, K.S., Specific effect of manganese on the allantoinase of Vigna radiata (1981) Phytochemistry, 20, pp. 2647-2650Wells, X.E., Lees, E.M., Properties of allantoinase from whole developing fruits of French bean, Phaseolus vulgaris L (1992) Australian Journal of Plant Physiology, 19, pp. 201-211Mary, A., Sastry, K.S., An unusual allantoinase from Dolichos biflorus (1978) Phytochemistry, 17, pp. 397-399Nirmala, J., Sastry, K.S., The allantoinase of Lathyrus sativus (1975) Phytochemistry, 14, pp. 1971-1973Piedras, P., Muñoz, A., Aguilar, M., Pineda, M., Allantoate amidinohydrolse (allantoicase) from Chlamydomonas reinhardtii: Its purification and catalytic and molecular characterization (2000) Archives of Biochemistry and Biophysics, 378, pp. 340-348Lukaszewski, K.M., Blevins, D.G., Randall, D.D., Asparagine and boric acid cause allantoate accumulation in soybean leaves by inhibiting manganese-dependent allantoate amidohydrolase (1992) Plant Physiology, 99, pp. 1670-1676Winkler, R.G., Polacco, J.C., Blevins, D.G., Randall, D.D., Enzymic degradation of allantoate in developing soybeans (1985) Plant Physiology, 79, pp. 787-793Raso, M.J., Muñoz, A., Pineda, M., Piedras, P., Biochemical characterisation of an allantoate-degrading enzyme from French bean (Phaseolus vulgaris): The requirement of phenylhydrazine (2007) Planta, 226, pp. 1333-1342Todd, C.D., Polacco, J.C., AtAAH encodes a protein with allantoate amidohydrolase activity from Arabidopsis thaliana (2006) Planta, 223, pp. 1108-1113Hanks, J.F., Tolbert, N.E., Schubert, K.R., Localization of enzymes of ureide biosynthesis in peroxisomes and microsomes nodules (1981) Plant Physiology, 68, pp. 65-69Wells, X.E., Lees, E.M., Ureidoglycolate amidohydrolase from developing French bean fruits (Phaseolus vulgaris L.) (1991) Archives of Biochemistry and Biophysics, 287, pp. 151-159Werner, A.K., Sparkes, I.A., Romeis, T., Witte, C.P., Identification, biochemical characterizaton, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean (2008) Plant Physiology, 146, pp. 418-430Singh, R., Evidence for presence of allantoicase in germinating peanuts (1968) Phytochemistry, 7, pp. 1503-1508Hoagland, D.R., Arnon, D.I., The water - Culture method for growing plants without soil (1950) California Agriculture Experimental Station Circular, 347, 39pVogels, G.D., Van Der Drift, C., Differential analyses of glyoxylate derivatives (1970) Analytical Biochemistry, 33, pp. 143-157Cocking, E.C., Yemm, E.W., Estimation of amino acids by ninhydrin (1954) Analyst, 80, pp. 209-213Cataldo, D.A., Haroon, M., Schrader, L.E., Youngs, V.L., Rapid colorimetric determination of nitrate in plant tissue by nitration of salicylic acid (1975) Communications in Soil Science and Plant Analysis, 6, pp. 71-80Jarret, H.W., Coosky, K.D., Ellis, B., Anderson, J.M., The separation of o-phtalaldehyde derivatives of amino acids by reversedphase chromatography on octylsilica column (1986) Analytical Biochemistry, 153, pp. 189-198Stumpf, D.K., Burris, R.H., A micromethod for the purification and quantification of organic acids of the tricarboxylic acid cycle in plant tissues (1979) Analytical Biochemistry, 95, pp. 311-315Xu, Z., De Windt, F.E., Van Der Drift, C., Purification and characterization of allantoate amidohydrolase from Bacillus fastidiosus (1995) Archives of Biochemistry and Biophysics, 324, pp. 99-104Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Analytical Biochemistry, 72, pp. 248-254