Fluconazole (FCZ) is synthetic antimycotic agent from azois group, with excellent bioavailability in body fluids and used for many treatments such as histoplasmoses, blastomycosis, and candidiasis. FCZ is considered the first chosen drug in the majority types of fungal meningitis. The objective of this work was to evaluate the physical-chemical characteristics of the FCZ in liquid pharmaceutical form and FCZ intestinal absorption in aqueous dispersion, in extemporaneous preparation. The FCZ intestinal absorption was evaluated through inverted intestinal sac and of the physical chemical stability through FCZ concentration in extemporaneous preparations. There is no quality guarantee in the extemporaneous preparation process, in the physical, chemical or biopharmaceutical view. The extemporaneous preparation were evaluated for 15 days and proved to be physically unstable. This may have influenced the FCZ intestinal absorption profile.265744747Rang, H.P., M.M. Dale, J. M. Ritter &ampP.K. Moore (2003) Farmacologia. Elsevier,Ed. 5a Ed. Rio De JaneiroNicolau, D.J., Crowe, H., Nightingale, C.H., Quintilliani, R., (1995) J. Antimicrob. Chemother, 36, pp. 395-401Yamreudeewong, W., Lopez-Anaya, A., Rappaport, H., (1993) Am. J. Hosp. Pharm, 50, pp. 2366-2367Souza, G.B., (2000) Manipulação Farmacêutica: Estabilidade De Formulações De Uso Hospitalar, , Ed. Do Autor Rio De JaneiroSingh, J., Burr, B., Stringham, D., Arrieta, A., (2001) Pediatrics Drugs, 3, pp. 733-761http://www.farmacopeia.org.br/downloads/pdf/6ed/fluconazol.pdf. Acessado em 5/março/2007