Intestinal Absorption And Physical Chemical Stability In Fluconazole Extemporaneous Preparations [absorção Intestinal E Estabilidade Físico- Química Em Preparações Extemporâneas De Fluconazol]

dc.creatorSeverino P.
dc.creatorZanchetta B.
dc.creatorFranco L.M.
dc.creatorPaganelli M.O.
dc.creatorTamascia P.A.
dc.creatorChaud M.V.
dc.date2007
dc.date2015-06-30T18:47:11Z
dc.date2015-11-26T14:35:40Z
dc.date2015-06-30T18:47:11Z
dc.date2015-11-26T14:35:40Z
dc.date.accessioned2018-03-28T21:39:05Z
dc.date.available2018-03-28T21:39:05Z
dc.identifier
dc.identifierLatin American Journal Of Pharmacy. , v. 26, n. 5, p. 744 - 747, 2007.
dc.identifier3262383
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-38049017951&partnerID=40&md5=1a5c5f067dab501757d5cff8dcd3c464
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/104771
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/104771
dc.identifier2-s2.0-38049017951
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1248436
dc.descriptionFluconazole (FCZ) is synthetic antimycotic agent from azois group, with excellent bioavailability in body fluids and used for many treatments such as histoplasmoses, blastomycosis, and candidiasis. FCZ is considered the first chosen drug in the majority types of fungal meningitis. The objective of this work was to evaluate the physical-chemical characteristics of the FCZ in liquid pharmaceutical form and FCZ intestinal absorption in aqueous dispersion, in extemporaneous preparation. The FCZ intestinal absorption was evaluated through inverted intestinal sac and of the physical chemical stability through FCZ concentration in extemporaneous preparations. There is no quality guarantee in the extemporaneous preparation process, in the physical, chemical or biopharmaceutical view. The extemporaneous preparation were evaluated for 15 days and proved to be physically unstable. This may have influenced the FCZ intestinal absorption profile.
dc.description26
dc.description5
dc.description744
dc.description747
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dc.descriptionhttp://www.farmacopeia.org.br/downloads/pdf/6ed/fluconazol.pdf. Acessado em 5/março/2007
dc.languagept
dc.publisher
dc.relationLatin American Journal of Pharmacy
dc.rightsfechado
dc.sourceScopus
dc.titleIntestinal Absorption And Physical Chemical Stability In Fluconazole Extemporaneous Preparations [absorção Intestinal E Estabilidade Físico- Química Em Preparações Extemporâneas De Fluconazol]
dc.typeArtículos de revistas


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