Artículos de revistas
Synthesis Of Methoxylated Goniothalamin, Aza-goniothalamin And γ-pyrones And Their In Vitro Evaluation Against Human Cancer Cells
Registro en:
Bioorganic And Medicinal Chemistry. , v. 20, n. 11, p. 3635 - 3651, 2012.
9680896
10.1016/j.bmc.2012.03.059
2-s2.0-84861198518
Autor
Barcelos R.C.
Pastre J.C.
Caixeta V.
Vendramini-Costa D.B.
De Carvalho J.E.
Pilli R.A.
Institución
Resumen
The present work describes the preparation of three novel series of compounds based on the structure of goniothalamin, a natural styryl lactone which has been found to display cytotoxic and antiproliferative activities against a variety of cancer cell lines. A focused library of 29 novel goniothalamin analogues was prepared and evaluated against seven human cancer cell lines. While the γ-pyrones and the aza-goniothalamin analogues were less potent than the lead compound, 2,4-dimethoxy analogue 88 has shown to be more potent in vitro than goniothalamin against all cancer cell lines evaluated. Furthermore, it was more potent than doxorubicin against NCI-ADR/RES, OVCAR-03 and HT-29 while being less toxic to human keratinocytes (HaCat). The 3,5-dimethoxy analogue 90 and 2,4,5-trimethoxy analogue 92 also displayed promising antiproliferative activity when compared to goniothalamin (1). 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