Synthesis Of Methoxylated Goniothalamin, Aza-goniothalamin And γ-pyrones And Their In Vitro Evaluation Against Human Cancer Cells

dc.creatorBarcelos R.C.
dc.creatorPastre J.C.
dc.creatorCaixeta V.
dc.creatorVendramini-Costa D.B.
dc.creatorDe Carvalho J.E.
dc.creatorPilli R.A.
dc.date2012
dc.date2015-06-26T20:30:14Z
dc.date2015-11-26T14:28:51Z
dc.date2015-06-26T20:30:14Z
dc.date2015-11-26T14:28:51Z
dc.date.accessioned2018-03-28T21:32:04Z
dc.date.available2018-03-28T21:32:04Z
dc.identifier
dc.identifierBioorganic And Medicinal Chemistry. , v. 20, n. 11, p. 3635 - 3651, 2012.
dc.identifier9680896
dc.identifier10.1016/j.bmc.2012.03.059
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84861198518&partnerID=40&md5=1b91f27adc1093663492f21476da7971
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/97272
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/97272
dc.identifier2-s2.0-84861198518
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1246699
dc.descriptionThe present work describes the preparation of three novel series of compounds based on the structure of goniothalamin, a natural styryl lactone which has been found to display cytotoxic and antiproliferative activities against a variety of cancer cell lines. A focused library of 29 novel goniothalamin analogues was prepared and evaluated against seven human cancer cell lines. While the γ-pyrones and the aza-goniothalamin analogues were less potent than the lead compound, 2,4-dimethoxy analogue 88 has shown to be more potent in vitro than goniothalamin against all cancer cell lines evaluated. Furthermore, it was more potent than doxorubicin against NCI-ADR/RES, OVCAR-03 and HT-29 while being less toxic to human keratinocytes (HaCat). The 3,5-dimethoxy analogue 90 and 2,4,5-trimethoxy analogue 92 also displayed promising antiproliferative activity when compared to goniothalamin (1). These results provide new elements for the design and synthesis of novel representatives of this family of natural compounds. © 2012 Elsevier Ltd. All rights reserved.
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dc.languageen
dc.publisher
dc.relationBioorganic and Medicinal Chemistry
dc.rightsfechado
dc.sourceScopus
dc.titleSynthesis Of Methoxylated Goniothalamin, Aza-goniothalamin And γ-pyrones And Their In Vitro Evaluation Against Human Cancer Cells
dc.typeArtículos de revistas


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