Artículos de revistas
Oxidative Damage Of Mitochondria Induced By Fe(ii)citrate Or T-butyl Hydroperoxide In The Presence Of Ca2+: Effect Of Coenzyme Q Redox State
Registro en:
Free Radical Biology And Medicine. , v. 18, n. 1, p. 55 - 59, 1995.
8915849
10.1016/0891-5849(94)00098-5
2-s2.0-0028843461
Autor
Castilho R.F.
Kowaltowski A.J.
Meinicke AndrR.
Vercesi A.E.
Institución
Resumen
The role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate. In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these prooxidants in the presence of Ca2+ is mediated by different mechanisms. © 1994. 18 1 55 59 Boveris, Oshino, Chance, The cellular production of hydrogen peroxide (1972) Biochem. J., 128, pp. 617-630 Reed, Review of the current status of calcium and thiols in cell injury (1990) Chemical Research in Toxicology, 5, pp. 495-502 Vercesi, Hoffmann, Generation of reactive oxygen metabolites and oxidative damage in mitochondria: The role of calcium (1993) Methods in toxicology: “Mitochondrial Dysfunction”, 2, pp. 256-265. , D.P. Jones, L.H. Lash, Academic Press, New York Cadenas, Boveris, Ragan, Stoppani, Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria (1977) Arch. Biochem. Biophys., 180, pp. 248-257 Beyer, The participation of coenzyme Q in free radical production and antioxidation (1990) Free Radic. Biol. Med., 8, pp. 545-565 Forsmark, Aberg, Norling, Nordenbrand, Dallner, Ernster, Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of Vitamine E (1991) FEBS Lett, 285, pp. 39-43 Bindoli, Lipid peroxidation in mitochondria (1988) Free Radical Biology and Medicine, 5, pp. 247-261 Gunter, Pfeiffer, Mechanisms by which mitochondria transport calcium (1990) Am. J. Physiol., 258, pp. C755-C786 Lehninger, Vercesi, Bababunmi, Regulation of Ca2+ release from mitochondria by the oxidation reduction state of pyridine nucleotides (1978) Proc. Natl. Acad. Sci. USA, 75, pp. 1690-1694 Crompton, Ellinger, Costi, Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress (1988) Biochem. J., 255, pp. 357-360 Fagian, Pereira-da-Silva, Martins, Vercesi, Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants (1990) J. Biol. Chem., 265, pp. 19955-19960 Valle, Fagian, Parentoni, Meinicke, Vercesi, The participation of reactive oxygen species and protein thiols in the mechanism of mitochondrial inner membrane permeabilization by calcium plus prooxidants (1993) Arch. Biochem. Biophys., 307, pp. 1-7 Szabo, Zoratti, The mitochondrial megachannel is the permeability transition pore (1992) Journal of Bioenergetics and Biomembranes, 24, pp. 111-117 Castilho, Meinicke, Almeida, Hermes-Lima, Vercesi, Oxidative damage of mitochondria induced by Fe(II)citrate is potentiated by Ca2+ and includes lipid peroxidation and alterations in membrane proteins (1994) Arch. Biochem. Biophys., 308, pp. 158-163 Pedersen, Greenalwalt, Reynafarje, Hullihen, Decker, Soper, Bustamante, Preparation and characterization of mitochondria and liver derived tissue (1978) Methods in Cell Biol., 20, pp. 411-481 Boveris, Cadenas, Stoppani, Role of ubiquinone in the mitochondrial generation of hydrogen peroxide (1976) Biochem. J., 156, pp. 435-444 Buege, Aust, Microsomal lipid peroxidation (1978) Methods in enzymology, 52, pp. 302-310. , S. Fleisher, L. Packer, Academic Press, New York Halliwell, Gutteridge, Lipid peroxidation: A radical chain reaction (1989) Free radicals in biology and medicine, pp. 234-260. , B. Halliwell, J.M.C. Gutteridge, Clarendon Press, Oxford Erdahl, Krebsbach, Pfeiffer, A comparison of phospholipid degradation by oxidation and hydrolysis during the mitochondrial permeability transition (1991) Arch. Biochem. Biophys., 285, pp. 252-260 Beyer, Nordenbrand, Ernster, The function of coenzyme Q in free radical production and as an antioxidant: A review (1987) Chem. Scripta, 27, pp. 145-153 Svingen, Buege, O'Neal, Aust, The mechanism of NADPH-dependent lipid peroxidation: The propagation of lipid peroxidation (1979) J. Biol. Chem., 254, pp. 5892-5899 Cadenas, Boveris, Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria (1980) Biochem. J., 188, pp. 31-37 Stadtman, Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions (1993) Annu. Rev. Biochem., 62, pp. 797-821