Oxidative Damage Of Mitochondria Induced By Fe(ii)citrate Or T-butyl Hydroperoxide In The Presence Of Ca2+: Effect Of Coenzyme Q Redox State

dc.creatorCastilho R.F.
dc.creatorKowaltowski A.J.
dc.creatorMeinicke AndrR.
dc.creatorVercesi A.E.
dc.date1995
dc.date2015-06-26T17:14:31Z
dc.date2015-11-26T14:20:23Z
dc.date2015-06-26T17:14:31Z
dc.date2015-11-26T14:20:23Z
dc.date.accessioned2018-03-28T21:22:02Z
dc.date.available2018-03-28T21:22:02Z
dc.identifier
dc.identifierFree Radical Biology And Medicine. , v. 18, n. 1, p. 55 - 59, 1995.
dc.identifier8915849
dc.identifier10.1016/0891-5849(94)00098-5
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028843461&partnerID=40&md5=f02350dfee5990aaac2363e57dfbbec3
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/95922
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/95922
dc.identifier2-s2.0-0028843461
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244229
dc.descriptionThe role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate. In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these prooxidants in the presence of Ca2+ is mediated by different mechanisms. © 1994.
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dc.description55
dc.description59
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dc.languageen
dc.publisher
dc.relationFree Radical Biology and Medicine
dc.rightsfechado
dc.sourceScopus
dc.titleOxidative Damage Of Mitochondria Induced By Fe(ii)citrate Or T-butyl Hydroperoxide In The Presence Of Ca2+: Effect Of Coenzyme Q Redox State
dc.typeArtículos de revistas


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