Artículos de revistas
Streptozotocin-induced Genotoxic Effects In Chinese Hamster Cells: The Resistant Phenotype Of V79 Cells
Registration in:
Mutation Research Letters. , v. 347, n. 2, p. 79 - 85, 1995.
1657992
10.1016/0165-7992(95)90074-8
2-s2.0-0028983225
Author
Capucci M.S.
Hoffmann M.E.
Natarajan A.T.
Institutions
Abstract
The genotoxic effects of the methylating agent streptozotocin (STZ) on Chinese hamster cells CHO-9 and V79 were evaluated. The induction of cell killing, chromosomal aberrations, sister-chromatid exchanges (SCEs) and mutations was analyzed. Comparisons were made with the the STZ aglyconic analogue N-methyl-N-nitrosourea (MNU). V79 cells were found to be more resistant than CHO-9 cells to STZ and MNU killing effects, as well as to the induction of chromosomal aberrations and SCEs; however, V79 and CHO-9 cells appeared to be equally sensitive to the induction of 6-thioguanine resistant mutants by STZ. These results suggest that an error-free mechanisms that tolerates DNA methylation damage confers a resistant phenotype to V79 cells to the genotoxic effects of methylation damage. © 1995. 347 2 79 85 Aquilina, Zijno, Moscufo, Dogliotti, Bignami, Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO-9 cells (1989) Carcinogenesis, 10, pp. 1219-1223 Baker, VanVoorhis, Spencer, HeLa cell variants that differ in sensitivity to monofunctional alkylating agents with independence of cytotoxic and mutagenic responses (1979) Proceedings of the National Academy of Sciences, 76, pp. 5233-5249 Capucci, Hoffmann, De Groot, Natarajan, Streptozotocin-induced toxicity and cell cycle delay in rodent cells (1995) Environ Mol Mutagen, , in press Day, III, Ziolkowski, Scudiero, Meyer, Libiniecki, Girardi, Galloway, Bynum, Defective repair of alkylated DNA by human tumor and SV-40 transformed human cell strains (1980) Nature, 288, pp. 724-727 Godfrey, Bouffler, Musk, Raman, Johnson, Mammalian cells share a common pathway for the relief of DNA replication arrest by O6-alkylguanine, incorporated 6-thioguanine and UV photoproducts (1992) Mutation Res., 274, pp. 225-235 Goldmaker, Cuzich, Thilly, Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation of methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine (1986) J. Biol. Chem., 261, pp. 12462-12471 Goth-Goldstein, Hughes, Characterization of a CHO variant in respect to alkylating agent-induced biological effects and DNA repair (1987) Mutation Res., 184, pp. 139-146 Ishida, Utsumi, Differences in induction of sister chromatid exchange in MNNG-resistant HeLa S3-Mer− cell lines (1990) Carcinogenesis, 11, pp. 1209-1212 Kaina, Correction of alkylation hypersensitivity of CHO-W27-1 by transfection with human DNA (1987) Carcinogenesis, 8, pp. 1935-1938 LeDoux, Woodley, Patton, Wilson, Mechanisms of nitrosourea-induced β-cell damage, Alterations in DNA (1986) Diabetes, 35, pp. 866-872 Loveless, Possible relevance of O6-alkylation of desoxyguanine to the mutagenicity and carcinogenicity of nitrosoamines and nitrosoamides (1969) Nature, 233, pp. 206-209 Morris, Heflich, Beranek, Kodell, Alkylation-induced sister-chromatid exchanges correlate with cell survival, not mutations (1982) Mutation Res., 293, pp. 119-132 Natarajan, Simons, Vogel, van Zeeland, Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA (1984) Mutation Res., 128, pp. 31-40 Pegg, Mammalian O6-alkylguanine-DNA-alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents (1990) Cancer Res., 50, pp. 6119-6129 Perry, Wolff, New Giemsa method for the differential staining of sister chromatids (1974) Nature, 251, pp. 156-158 Samson, Linn, DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells (1987) Carcinogenesis, 8, pp. 227-230 Suter, Brennand, McMillan, Fox, Relative mutagenicity of antineoplastic drugs and other alkylating agents in V79 Chinese hamster cells, independence of cytotoxicity and mutagenic responses (1980) Mutation Res., 73, pp. 171-181 Swann, Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkyguanine and O4-alkylthymine and the mutagenic properties of these bases (1990) Mutation Res., 233, pp. 81-94 Tjälve, Streptozotocin: distribution, metabolism and mechanisms of action (1983) Uppsala J. Med. Sci., pp. 145-157 Warren, Crathorn, Shooter, The stability of methylated purines and of methylphosphotriesters in the DNA of V79 cells after treatment with N-methyl-N-nitrosourea (1979) Biochim. Biophys. Acta, 563, pp. 82-88