Streptozotocin-induced Genotoxic Effects In Chinese Hamster Cells: The Resistant Phenotype Of V79 Cells

dc.creatorCapucci M.S.
dc.creatorHoffmann M.E.
dc.creatorNatarajan A.T.
dc.date1995
dc.date2015-06-26T17:14:00Z
dc.date2015-11-26T14:19:58Z
dc.date2015-06-26T17:14:00Z
dc.date2015-11-26T14:19:58Z
dc.date.accessioned2018-03-28T21:21:33Z
dc.date.available2018-03-28T21:21:33Z
dc.identifier
dc.identifierMutation Research Letters. , v. 347, n. 2, p. 79 - 85, 1995.
dc.identifier1657992
dc.identifier10.1016/0165-7992(95)90074-8
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028983225&partnerID=40&md5=a87d0368c6fd03d87279677fbf8ed9a1
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/95835
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/95835
dc.identifier2-s2.0-0028983225
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244104
dc.descriptionThe genotoxic effects of the methylating agent streptozotocin (STZ) on Chinese hamster cells CHO-9 and V79 were evaluated. The induction of cell killing, chromosomal aberrations, sister-chromatid exchanges (SCEs) and mutations was analyzed. Comparisons were made with the the STZ aglyconic analogue N-methyl-N-nitrosourea (MNU). V79 cells were found to be more resistant than CHO-9 cells to STZ and MNU killing effects, as well as to the induction of chromosomal aberrations and SCEs; however, V79 and CHO-9 cells appeared to be equally sensitive to the induction of 6-thioguanine resistant mutants by STZ. These results suggest that an error-free mechanisms that tolerates DNA methylation damage confers a resistant phenotype to V79 cells to the genotoxic effects of methylation damage. © 1995.
dc.description347
dc.description2
dc.description79
dc.description85
dc.descriptionAquilina, Zijno, Moscufo, Dogliotti, Bignami, Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO-9 cells (1989) Carcinogenesis, 10, pp. 1219-1223
dc.descriptionBaker, VanVoorhis, Spencer, HeLa cell variants that differ in sensitivity to monofunctional alkylating agents with independence of cytotoxic and mutagenic responses (1979) Proceedings of the National Academy of Sciences, 76, pp. 5233-5249
dc.descriptionCapucci, Hoffmann, De Groot, Natarajan, Streptozotocin-induced toxicity and cell cycle delay in rodent cells (1995) Environ Mol Mutagen, , in press
dc.descriptionDay, III, Ziolkowski, Scudiero, Meyer, Libiniecki, Girardi, Galloway, Bynum, Defective repair of alkylated DNA by human tumor and SV-40 transformed human cell strains (1980) Nature, 288, pp. 724-727
dc.descriptionGodfrey, Bouffler, Musk, Raman, Johnson, Mammalian cells share a common pathway for the relief of DNA replication arrest by O6-alkylguanine, incorporated 6-thioguanine and UV photoproducts (1992) Mutation Res., 274, pp. 225-235
dc.descriptionGoldmaker, Cuzich, Thilly, Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation of methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine (1986) J. Biol. Chem., 261, pp. 12462-12471
dc.descriptionGoth-Goldstein, Hughes, Characterization of a CHO variant in respect to alkylating agent-induced biological effects and DNA repair (1987) Mutation Res., 184, pp. 139-146
dc.descriptionIshida, Utsumi, Differences in induction of sister chromatid exchange in MNNG-resistant HeLa S3-Mer− cell lines (1990) Carcinogenesis, 11, pp. 1209-1212
dc.descriptionKaina, Correction of alkylation hypersensitivity of CHO-W27-1 by transfection with human DNA (1987) Carcinogenesis, 8, pp. 1935-1938
dc.descriptionLeDoux, Woodley, Patton, Wilson, Mechanisms of nitrosourea-induced β-cell damage, Alterations in DNA (1986) Diabetes, 35, pp. 866-872
dc.descriptionLoveless, Possible relevance of O6-alkylation of desoxyguanine to the mutagenicity and carcinogenicity of nitrosoamines and nitrosoamides (1969) Nature, 233, pp. 206-209
dc.descriptionMorris, Heflich, Beranek, Kodell, Alkylation-induced sister-chromatid exchanges correlate with cell survival, not mutations (1982) Mutation Res., 293, pp. 119-132
dc.descriptionNatarajan, Simons, Vogel, van Zeeland, Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA (1984) Mutation Res., 128, pp. 31-40
dc.descriptionPegg, Mammalian O6-alkylguanine-DNA-alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents (1990) Cancer Res., 50, pp. 6119-6129
dc.descriptionPerry, Wolff, New Giemsa method for the differential staining of sister chromatids (1974) Nature, 251, pp. 156-158
dc.descriptionSamson, Linn, DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells (1987) Carcinogenesis, 8, pp. 227-230
dc.descriptionSuter, Brennand, McMillan, Fox, Relative mutagenicity of antineoplastic drugs and other alkylating agents in V79 Chinese hamster cells, independence of cytotoxicity and mutagenic responses (1980) Mutation Res., 73, pp. 171-181
dc.descriptionSwann, Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkyguanine and O4-alkylthymine and the mutagenic properties of these bases (1990) Mutation Res., 233, pp. 81-94
dc.descriptionTjälve, Streptozotocin: distribution, metabolism and mechanisms of action (1983) Uppsala J. Med. Sci., pp. 145-157
dc.descriptionWarren, Crathorn, Shooter, The stability of methylated purines and of methylphosphotriesters in the DNA of V79 cells after treatment with N-methyl-N-nitrosourea (1979) Biochim. Biophys. Acta, 563, pp. 82-88
dc.languageen
dc.publisher
dc.relationMutation Research Letters
dc.rightsfechado
dc.sourceScopus
dc.titleStreptozotocin-induced Genotoxic Effects In Chinese Hamster Cells: The Resistant Phenotype Of V79 Cells
dc.typeArtículos de revistas


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