Ectodermal dysplasia (ED) encompasses a group of hereditary disorders in which two or more ectoderm-derived structures are affected. Patients afflicted with this disorder exhibit hypoplasia or aplasia of different structures such as skin, hair, nails, teeth, and sweat glands among others. Dental treatment is of the utmost importance in order to improve the subject’s quality of life. The case here reported depicts a male patient affected with Christ-SiemensTouraine syndrome, who sought treatment due to tooth anodontia in upper and lower jaws. A dental approach was conducted involving periodontal treatment, oral rehabilitation and implantology, a social component was also furthered, directed to re-establish function and esthetics of the stomatognatic system. Performed treatment achieved absolute improvement in the masticatory process and esthetic smile which was satisfactory for the patient and his legal representative.