El presente artículo analiza la manifestación de la equidad, la eficiencia y la sustentabilidad en las regiones de México, a partir de su desarrollo humano durante el periodo 1950-2003. Se propone como metodología la medición de las desigualdades regionales por medio de la entropía absoluta y relativa de los indicadores del desarrollo humano y la sustentabilidad. La hipótesis contrastada es que las desigualdades regionales producto del desarrollo han aumentado en México durante el periodo 1950-2003, y que en fechas recientes los desequilibrios identificados mediante la evaluación de la sustentabilidad regional aun tienden a ser mayores. Finalmente, trata de propiciar la reflexión acerca de cuáles pueden ser algunas de las causas que propician las desigualdades actuales de las grandes regiones mexicanas.This article analyzes the manifestation of equity, efficiency and sustainability in Mexico's regions, starting from its human development during the period 1950-2003. As methodology it proposes the measurement of regional inequalities through the absolute and relative entropy of human development and sustainability indicators. The contrasted hypothesis is that the regional inequalities produced by development have increased in Mexico during the period 1950-2003, and that recently the disequilibria identified by the evaluation of regional sustainability tends to be greater still. Finally, it aims at promoting reflection on what might be some of the causes behind the present inequalities in Mexico's large regions.This article analyzes the manifestation of equity, efficiency and sustainability in Mexico's regions, starting from its human development during the period 1950-2003. As methodology it proposes the measurement of regional inequalities through the absolute and relative entropy of human development and sustainability indicators. The contrasted hypothesis is that the regional inequalities produced by development have increased in Mexico during the period 1950-2003, and that recently the disequilibria identified by the evaluation of regional sustainability tends to be greater still. Finally, it aims at promoting reflection on what might be some of the causes behind the present inequalities in Mexico's large regions.O presente artigo analisa a manifestação da equidade, a eficiência e a sustentabilidade nas regiões do México, a partir do seu desenvolvimento humano durante o período 1950-2003. Propõe-se como metodologia a medição das desigualdades regionais por meio da entropía absoluta e relativa dos indicadores de desenvolvimento humano e a sustentabilidade. A hipótese contrastada é que as desigualdades regionais produto do desenvolvimento aumentaram no México durante o período 1950-2003, e que em datas recentes os desequilíbrios identificados mediante a avaliação da sustentabilidade regional tendem a ser ainda maiores. Finalmente, trata-se de propiciar a reflexão sobre quais podem ser algumas das causas que propiciam as desigualdades atuais das grandes regiões mexicanas.