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Pharmacokinetic considerations in critically ill patients Consideraciones farmacocinéticas en el paciente crítico
(2012)
Critically ill patients in Intensive Care Units (ICUs) are exposed to multiple procedures and usually require complex treatment regimens. Many of them suffer from comorbidities and different complications such as organ ...
Pharmacokinetics of propofol in 10 to 15 days old foals
(UNIV AUSTRAL CHILE. FAC CIENCIAS VETERINARIAS, 2000)
The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats
(Wiley-Blackwell, 2007-11-01)
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic ...
The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats
(Wiley-Blackwell, 2007-11-01)
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic ...
Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing
(Elsevier, 2020-12-01)
SARS-CoV-2 utilizes the IMPα/β1 heterodimer to enter host cell nuclei after gaining cellular access through the ACE2 receptor. Ivermectin has shown antiviral activity by inhibiting the formation of the importin-α (IMPα) ...
In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property
(Wiley-Blackwell, 2012-11-01)
Primaquine is an important therapeutic resource for malaria treatment and it has wide activity against several pathogens. The haematotoxicity of primaquine is the major problem for its therapeutic application. This effect ...
In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property
(Wiley-Blackwell, 2012-11-01)
Primaquine is an important therapeutic resource for malaria treatment and it has wide activity against several pathogens. The haematotoxicity of primaquine is the major problem for its therapeutic application. This effect ...
Effects of dosage, comorbidities, and food on isoniazid pharmacokinetics in Peruvian tuberculosis patients
(American Society for Microbiology, 2014)
Poor response to tuberculosis (TB) therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic (PK) parameters can be affected by several factors, such as comorbidities or the interaction ...