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Identificação e quantificação das isoformas da heparanase em plasma de pacientes com carcinomas gatrointestinais
(Universidade Federal de São Paulo (UNIFESP), 2009-03-25)
Heparanase-1 (HPA1) is an endo-β-glucuronidase that degrades intradisaccharides glycosidic linkage between hexosamine and glucuronic acid into heparan sulfate chains, present on extracellular matrix and surface proteoglycans. ...
Mechanisms of Cellular Uptake, Intracellular Transportation, and Degradation of CIGB-300, a Tat-Conjugated Peptide, in Tumor Cell Lines
(American Chemical Society, 2014-04)
CIGB-300 is a cyclic synthetic peptide that induces apoptosis in malignant cells, elicits antitumor activity in cancer animal models, and shows tumor reduction signs when assayed in first-in-human phase I trial in patients ...
Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK)
(Associação Brasileira de Divulgação Científica, 2010-10-01)
Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals. We ...
Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabilization
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Crotamine, one of the main toxic components of Crotalus durissus terrificus venom, is a small non-enzymatic basic polypeptide, which causes hind limb paralysis and necrosis of muscle cells. it is well-known that several ...
Lepstospira interrogans shotgun phage display identified LigB as a heparin-binding protein
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
LigB is an adhesin from pathogenic Leptospira that is able to bind to extracellular matrix and is considered a virulence factor. A shotgun phage display genomic library was constructed and used for panning against Heparan ...
INVOLVEMENT OF THE STAGE-SPECIFIC 82-KILODALTON ADHESION MOLECULE OF TRYPANOSOMA-CRUZI METACYCLIC TRYPOMASTIGOTES IN HOST-CELL INVASION
(Amer Soc Microbiology, 1993-09-01)
This study provides several pieces of evidence indicating that 3F6-Ag, identified by monoclonal antibody (MAb) 3F6 as a stage-specific glycoprotein of approximately 82 kDa on the surface of metacyclic trypomastigotes of ...
Lepstospira interrogans shotgun phage display identified LigB as a heparin-binding protein
(Elsevier B.V., 2012-11-02)
LigB is an adhesin from pathogenic Leptospira that is able to bind to extracellular matrix and is considered a virulence factor. A shotgun phage display genomic library was constructed and used for panning against Heparan ...
Pro-angiogenic effects of pregnancy-specific glycoproteins in endothelial and extravillous trophoblast cells
(BioScientifica, 2020-11)
We previously reported that binding to heparan sulfate (HS) is required for the ability of the placentally secreted pregnancy-specific glycoprotein 1 (PSG1) to induce endothelial tubulogenesis. PSG1 is composed of four ...
GPC3 reduces cell proliferation in renal carcinoma cell lines
(Biomed Central Ltd, 2014-08-29)
Background: Glypican 3 (GPC3) is a member of the family of glypican heparan sulfate proteoglycans (HSPGs). The GPC3 gene may play a role in controlling cell migration, negatively regulating cell growth and inducing apoptosis. ...