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Sequenciamento de genoma completo do cavalo Nordestino para identificação de variantes genômicas (SNVs e INDELs) e validação em subpopulações remanescentes
(Universidade Federal de Minas GeraisBrasilVET - DEPARTAMENTO DE ZOOTECNIAPrograma de Pós-Graduação em ZootecniaUFMG, 2020-02-28)
Genomic variant calling, in order to identify new single nucleotide variants (SNVs) and insertions/deletions (InDELs), potentially associated with the characteristics of rusticity and resistance to arid climate in Nordestino ...
Stability of the resistance to the thiosemicarbazone derived from 5,6-Dimethoxy-1-indanone, a non-nucleoside polymerase inhibitor of bovine viral diarrhea virus
(Public Library Of Science, 2014-06)
Bovine viral diarrhea virus (BVDV) is the prototype Pestivirus. BVDV infection is distributed worldwide and causes serious problems for the livestock industry. The thiosemicarbazone of 5,6-dimethoxy-1-indanone (TSC) is a ...
Perfil de mutações de resistência e polimorfismos genéticos em variantes do vírus da hepatite B circulantes na região de Botucatu
(Universidade Estadual Paulista (Unesp), 2014-02-28)
A infecção pelo vírus da hepatite B (VHB) constitui um grave problema de saúde pública mundial, sendo responsável por doenças hepáticas agudas, crônicas, cirrose e hepatocarcinoma. Com o intuito de diminuir a replicação ...
Prevalence of naturally occurring protease inhibitor resistance-associated variants in hemodialysis and renal transplant patients with hepatitis C virus infection
(Lippincott Williams & Wilkins, 2017)
Background NS3 protease inhibitors (PIs) were the first direct antiviral agents used for the treatment of hepatitis C virus. The combination of second-wave PIs with other direct antiviral agents enabled the use of ...
Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats
(Academic Press Ltd - Elsevier Science Ltd, 2019-03)
Brucellosis is an important zoonotic disease caused by infection with Brucella spp. It generates major economic losses in livestock production worldwide. Goats are the principal hosts of B. melitensis, the main infection ...
Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru
(Public Library of Science, 2017)
BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic ...
Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil
(Public Library of Science, 2019)
Hepatitis C virus resistance to the new direct-acting antivirals
(Informa Healthcare, 2016-07)
Introduction: The treatment of hepatitis C virus (HCV) infection has dramatically improved in recent years with the widespread use of interferon-free combination regimens. Despite the high sustained virological response ...