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ADP-ribosylation: From molecular mechanisms to human disease
(Sociedade Brasileira de Genética, 2020-01)
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of ...
Clonado, caracterización y estudios funcionales de las enzimas poli (ADP-ribosa)polimerasa y poli (ADP-ribosa) glicohidrolasa de Trypanosoma bruceiCloning, characterization and functional studies of poly (ADP-ribose) polymerase and poly (ADP-ribose) glycohydrolase enzimes of Trypanosoma brucei
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2015)
Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease
(2018)
We have proposed that a common biological mechanism deregulated in opposite directions might explain the inverse epidemiological association observed between Alzheimer's disease (AD) and cancer. Accordingly, we showed that ...
PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors
(MDPI AG, 2020-11-05)
Poly(ADP-ribosyl)polymerase (PARP) synthesizes poly(ADP-ribose) (PAR), which is anchored to proteins. PAR facilitates multiprotein complexes’ assembly. Nuclear PAR affects chromatin’s structure and functions, including ...
PARP Activity Fine-tunes the DNA Replication Choreography of Chk1-depleted Cells
(Academic Press Ltd - Elsevier Science Ltd, 2021-05-18)
Checkpoint Kinase 1 (Chk1) prevents DNA damage by adjusting the replication choreography in the face of replication stress. Chk1 depletion provokes slow and asymmetrical fork movement, yet the signals governing such changes ...
Neutrophils recruitment during sepsis: Critical points and crossroads
(FRONTIERS IN BIOSCIENCE INC, 2009)
The mechanisms that initiate an inflammatory systemic response to a bacterial infection lead to a high mortality and constitute the first cause of death in Critical Care Units (ICU`s). Sepsis is a poorly understood disease ...
Further studies on the hypothesis of PARP-1 inhibition as a strategy for lessening the long-term effects produced by perinatal asphyxia: Effects of nicotinamide and theophylline on PARP-1 activity in brain and peripheral tissue
(2012)
Oxygen interruption leads to death when reoxygenation is not promptly re-established. Re-oxygenation triggers a cascade of biochemical events for restoring function at the cost of improper homeostasis. The effects observed ...
Poly(ADP-ribose) metabolism in human parasitic protozoa
(Elsevier Science, 2020-08-22)
Poly(ADP-ribosyl)ation reactions constitute a post-translational protein modification synthesized in higher eukaryotes by a family of poly(ADP-ribose)polymerases (PARP) and catabolized mainly by poly(ADP-ribose) glycohydrolase ...
Gold nanorods/siRNA complex administration for knockdown of PARP-1: A potential treatment for perinatal asphyxia
(Dove Medical Press Ltd., 2018)
Background: Perinatal asphyxia interferes with neonatal development, resulting in long-term deficits associated with systemic and neurological diseases. Despite the important role of poly (ADP-ribose) polymerase 1 (PARP-1) ...