info:eu-repo/semantics/article
ADP-ribosylation: From molecular mechanisms to human disease
Fecha
2020-01Registro en:
Hoch, Nicolas Carlos; Polo Ilacqua, Luis Mariano; ADP-ribosylation: From molecular mechanisms to human disease; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 43; 1; 1-2020; 1-14
1415-4757
1678-4685
CONICET Digital
CONICET
Autor
Hoch, Nicolas Carlos
Polo Ilacqua, Luis Mariano
Resumen
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.