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Evaluating kinetic and physiological features of rCHO-K1 cells cultured on microcarriers for production of a recombinant metalloprotease/disintegrin
(Pontificia Universidad Católica de Valparaíso, 2007)
Proliferation of 3T3 fibroblasts in a spinner type Reactor on microcarriers of fibrin-alginate
(2015-01)
- The microcarriers have become an alternative of
cell culture in order to increase the contact area per unit volume
of culture medium. The aim of this work is the fabrication of
microcarriers from a mixture of sodium ...
Vero cell upstream bioprocess development for the production of viral vectors and vaccines
The Vero cell line is considered the most used continuous cell line for the production of viral vectors and
vaccines. Historically, it is the first cell line that was approved by the WHO for the production of human vaccines. ...
Expansão de células mesenquimais estromais em frasco spinner e avaliação de aditivos para diminuir a aglomeração de microcarregadores
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Biotecnologia - PPGBiotec, 2013-04-29)
The increasing interest in the employment of multipotent mesenchymal stromal cells (MSCs) to applications in tissue engineering and cell therapy is mainly attributed to their plasticity and regenerative capacity. The MSCs ...
Immobilization of primary cultures of insulin-releasing human pancreatic cells
(LANDES BIOSCIENCE, 2009)
Transplantation of pancreatic islets isolated from organ donors constitutes a promising alternative treatment for type 1 diabetes, however, it is severely limited by the shortage of organ donors. Ex vivo islet cell cultures ...
Improved Bioprocess with CHO-hTSH Cells on Higher Microcarrier Concentration Provides Higher Overall Biomass and Productivity for rhTSH
(HUMANA PRESS INC, 2011)
Since the recombinant thyroid-stimulating hormone (rhTSH) is secreted by stably transfected Chinese hamster ovary (CHO-hTSH) cells, a bioprocess consisting of immobilizing the cells on a substrate allowing their multiplication ...
Expansão de células-tronco mesenquimais em biorreator single-use com movimento ondulatório visando aplicações terapêuticas
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Engenharia Química - PPGEQCâmpus São Carlos, 2019-04-30)
Mesenchymal Stem/Stromal Cells (MSCs) and MSC-derived Extracellular Vesicles (EVs) are being targeted in different medical areas. The MSCs are present in small proportions in tissues, thus making an in vitro expansion ...
Desenvolvimento de processo de inoculação com microcarregador Cytoline 1 visando o cultivo de célula CHO-K1 em biorreator de leito fixo
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Engenharia Química - PPGEQ, 2004-08-20)
The use of the technology of animal cell culture for the expression of recombinant proteins has been gaining major interest within biotechnology due the obtation of recent efficient medicaments in the chronic diseases. In ...