Buscar
Mostrando ítems 11-20 de 107
Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors
(HOSPITAL CLINICAS, UNIV SAO PAULOSAO PAULO, 2012)
OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional ...
Immobilized Kidney 28-kDa Endostatin- Related (KES28kDa) Fragment Promotes Endothelial Cell Survival
(KARGER, 2010)
Background/Objective: Renal ischemia-hypoxia is a leading cause of acute kidney injury (AKI). Ischemia causes extracellular matrix breakdown of the tubular basement membrane. Endostatin (ES) is the C-terminal fragment of ...
Continuous and High-Level In Vivo Delivery of Endostatin From Recombinant Cells Encapsulated in TheraCyte (R) Immunoisolation Devices
(COGNIZANT COMMUNICATION CORP, 2010)
Endostatin (ES) is a potent inhibitor of angiogenesis and tumor growth. Continuous ES delivery of ES improves the efficacy and potency of the antitumoral therapy. The TheraCyte (R) system is a polytetrafluoroethylene (PTFE) ...
Fibronectin expression is decreased in metastatic renal cell carcinoma following endostatin gene therapy
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERPARIS, 2012)
Tumor cells induce the disruption of homeostasis between cellular and extracellular compartments to favor tumor progression. The expression of fibronectin (FN), a matrix glycoprotein, is increased in several carcinoma cell ...
Fibronectin expression is decreased in metastatic renal cell carcinoma following endostatin gene therapy
(Elsevier B.V., 2012-09-01)
Tumor cells induce the disruption of homeostasis between cellular and extracellular compartments to favor tumor progression. the expression of fibronectin (FN), a matrix glycoprotein, is increased in several carcinoma cell ...
Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma
(Federation Amer Soc Exp Biol, 2007-10-01)
We investigated whether transfer of the gene encoding the angiogenesis inhibitor endostatin into the NIH/3T3 fibroblast cell line could inhibit renal tumor growth in vivo. NIH/3T3 cells were transduced with retroviral ...
Endostatin gene therapy enhances the efficacy of IL-2 in suppressing metastatic renal cell carcinoma in mice
(SPRINGER, 2010)
We investigated whether the administration of IL-2 combined with endostatin gene therapy was able to produce additive or even synergistic immunomodulatory activity in a mouse model of metastatic renal carcinoma. Renca cells ...
Endostatin gene therapy enhances the efficacy of IL-2 in suppressing metastatic renal cell carcinoma in mice
(Springer, 2010-09-01)
We investigated whether the administration of IL-2 combined with endostatin gene therapy was able to produce additive or even synergistic immunomodulatory activity in a mouse model of metastatic renal carcinoma. Renca cells ...