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Determination of enantiomeric composition of ibuprofen in pharmaceutical formulations by partial least-squares regression of strongly overlapped chromatographic profiles
(Elsevier Science, 2012-02)
In this report, we demonstrate how chiral liquid chromatography combined with multivariate chemometric techniques, specifically unfolded-partial least-squares regression (U-PLS), provides a powerful analytical methodology. ...
Permethylated β-cyclodextrin in liquid poly(oxyethylene) as a stationary phase for capillary gas chromatography
(Elsevier Science, 2009-10)
This paper reports the study of poly(oxyethylene) as a solvent for heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (PM-β-CD) and the potential of these mixtures for constructing enantioselective gas chromatography columns. ...
Synthesis and evaluation of a chiral stationary phase based on quinine: Enantioresolution of dinitrophenyl derivatives of α-amino acids
(Elsevier Science, 2011-06)
The natural alkaloid quinine (QN) was immobilized on porous silica particles, and part of the material was subsequently endcapped with n-hexyl hydrocarbon chains. Two synthetic strategies for silanization of the support ...
Desenvolvimento de métodos analíticos quirais para quantificação dos enantiômeros da cloroquina em comprimidos e em plasma humano
(Universidade Federal de Minas GeraisUFMG, 2017-02-17)
Malaria is a disease with high epidemic potential, representing a serious public health problem in the world. In Brazil, chloroquine is the drug of first choice for the treatment of malaria caused by Plasmodium vivax. ...
Investigação in vitro do efeito da restrição proteica no metabolismo do albendazol em ratos e estudos de inibição do crescimento de células tumorais humanas pelos enantiômeros do albendazol sulfóxido
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2011-12-02)
This work presents an in vitro investigation of protein restriction in the metabolism of albendazole (ABZ). The study was conducted with microsomal fractions obtained from Wistar rats using a High Performance Multidimensional ...
Experimental determination of chromatographic separation parameters of ketamine enantiomers on MCTA
(Elsevier Science BvAmsterdamHolanda, 2005)