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Production of Cell-Penetrating Peptides in Escherichia coli Using an Intein-Mediated System
(Springer, 2015)
Cell-penetrating peptides are molecules with the ability to cross membranes and
enter cells. Attention has been put on these peptides as a tool for drug delivery research, as they
are able to serve as delivery vectors ...
Modification of the linker amino acid in the cell-penetrating peptide NickFect55 leads to enhanced pDNA transfection for in vivo applications
(MDPI, 2023-02-20)
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors. ...
Synthesis and cytotoxicity of a ruthenium nitrosyl nitric oxide donor with isonicotinic acid and a cell penetrating peptide
(2013-02-01)
The syntheses and properties of trans-[Ru(NH3) 4(L)(NO)](BF4)3 (L = isonicotinic acid (inaH) (I) or ina-Tat48-60 (II)) are described. Tat48-60, a cell penetrating peptide fragment of the Tat regulatory protein of the HIV ...
Synthesis and cytotoxicity of a ruthenium nitrosyl nitric oxide donor with isonicotinic acid and a cell penetrating peptide
(2013-02-01)
The syntheses and properties of trans-[Ru(NH3) 4(L)(NO)](BF4)3 (L = isonicotinic acid (inaH) (I) or ina-Tat48-60 (II)) are described. Tat48-60, a cell penetrating peptide fragment of the Tat regulatory protein of the HIV ...
Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides derived from TIRAP
(2012)
In order to develop future therapeutic applications for cell penetrating peptides (CPPs), it is essential to characterize their internalization mechanisms, as they might affect the stability and the accessibility of the ...
Aggregation limiting cell-penetrating peptides derived from protein signal sequences
(MDPI, 2023-02-16)
Alzheimer’s disease (AD) is the most common neurodegenerative disease (ND) and the leading cause of dementia. It is characterized by non-linear, genetic-driven pathophysiological dynamics with high heterogeneity in the ...
Designing improved active peptides for therapeutic approaches against infectious diseases
(Pergamon-Elsevier Science Ltd, 2018-03)
Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms’ resistance to conventional drugs has been increasing, and it is now pinpointed as a major ...
Improving cell penetration of gold nanorods by using an amphipathic arginine rich peptide
(Dove Medical Press, 2020)
Introduction: Gold nanorods are highly reactive, have a large surface-to-volume ratio, and can be functionalized with biomolecules. Gold nanorods can absorb infrared electromagnetic radiation, which is subsequently dispersed ...
Adsorption and insertion of polyarginine peptides into membrane pores: the trade-off between electrostatics, acid-base chemistry and pore formation energy
(Academic Press Inc Elsevier Science, 2019-09)
The mechanism that arginine-rich cell penetrating peptides (ARCPPs) use to translocate lipid membranes is not entirely understood. In the present work, we develop a molecular theory that allows to investigate the adsorption ...
The Natural Cell-Penetrating Peptide Crotamine Targets Tumor Tissue in Vivo and Triggers a Lethal Calcium-Dependent Pathway in Cultured Cells
(AMER CHEMICAL SOCWASHINGTON, 2012)
Our goal was to demonstrate the in vivo tumor specific accumulation of crotamine, a natural peptide from the venom of the South American rattlesnake Crotalus durissus terrificus, which has been characterized by our group ...