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Mostrando ítems 31-40 de 44
Allosteric Pathways In The Ppar Gamma-rxr Alpha Nuclear Receptor Complex
(NATURE PUBLISHING GROUPLONDON, 2016)
Unmasking Determinants of Specificity in the Human Kinome
(Cell Press, 2015-09)
Protein kinases control cellular responses to environmental cues by swift and accurate signal processing. Breakdowns in this high-fidelity capability are a driving force in cancer and other diseases. Thus, our limited ...
Signal Transmission in Escherichia coli Cyclic AMP Receptor Protein for Survival in Extreme Acidic Conditions
(American Chemical Society, 2021-10-12)
During the life cycle of enteric bacterium Escherichia coli, it encounters a wide spectrum of pH changes. The asymmetric dimer of the cAMP receptor protein, CRP, plays a key role in regulating the expressions of genes and ...
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase
(Cell Press, 2016-10)
Allostery is a phenomenon observed in many proteins where binding of a macromolecular partner or a small-molecule ligand at one location leads to specific perturbations at a site not in direct contact with the region where ...
Estudo da dinâmica e caracterização estrutural da interface proteica em Quimeras Xilanase-XBP por simulação molecular
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA, 2019-07-17)
In the field of molecular biology and biotechnology, proteins owning two or more combined
activities, coupled with an appropriate structural stability, have been widely applied. A few
years ago three hybrid enzymes / ...
Dinâmica estrutural da proteína adaptadora Grb2, seu domínio SH2 e a interação com cumarina por ressonância magnética nuclear e fluorescência
(Universidade Estadual Paulista (Unesp), 2019-04-12)
As células são submetidas a um constante e preciso controle de sobrevivência, crescimento, diferenciação e apoptose. Durante o processo de proliferação celular, estas também estão sujeitas a erros que podem gerar perda de ...
S-nitrosoglutathione Inhibits Inducible Nitric Oxide Synthase Upregulation By Redox Posttranslational Modification In Experimental Diabetic Retinopathy
(Association for Research in Vision and Ophthalmology Inc., 2014)
Efectos fisiológicos evidenciados a partir de cambios en hígado y riñón, asociados a la separación materna y al consumo de glutamato monosódico.
(Universidad Nacional de Colombia - Sede Bogotá, 2019-12-08)
Most mammals share in the early stages of life a bond given by the mother-child relationship. It has been demonstrated that the interruption of this bond given by maternal separation during lactation (SMDL) generates ...
Enseñanza y aprendizaje de conceptos asociados a la cinética enzimática en el contexto de la bioquímica de alimentos.
(Universidad Pedagógica NacionalLicenciatura en QuímicaFacultad de Ciencia y Tecnología, 2022)
Este trabajo de grado se propone el diseño de una unidad didáctica enmarcada en el modelo Aprendizaje Basado en Problemas (ABP) para la enseñanza de conceptos asociados a la cinética enzimática. En donde se plantea tres ...