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Creating and validating a warfarin pharmacogenetic dosing algorithm for colombian patients
Purpose: Warfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter-and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. CYP2C9 ...
Pharmacogenetics of Warfarin: Development of a Dosing Algorithm for Brazilian Patients
(NATURE PUBLISHING GROUP, 2008)
A dosing algorithm including genetic (VKORC1 and CYP2C9 genotypes) and nongenetic factors (age, weight, therapeutic indication, and cotreatment with amiodarone or simvastatin) explained 51% of the variance in stable weekly ...
VKORC1 V66M mutation in African Brazilian patients resistant to oral anticoagulant therapy
(Pergamon-elsevier Science LtdOxfordInglaterra, 2010)
Evaluation of a pharmacogenetic-based warfarin dosing algorithm in patients with low time in therapeutic range – study protocol for a randomized controlled trial
(BioMed Central, 2016)
Abstract
Background
Time in therapeutic range (TTR) is a measurement of quality of warfarin therapy and lower TTR values (<50%) are associated with greater risk of ...
Evaluation of a pharmacogenetic-based warfarin dosing algorithm in patients with low time in therapeutic range – study protocol for a randomized controlled trial
(2016-11-17)
Abstract
Background
Time in therapeutic range (TTR) is a measurement of quality of warfarin therapy and lower TTR values (<50%) are associated with greater risk of thromboembolic ...
Fatores genéticos e não genéticos relacionados às doses de varfarina e à qualidade da anticoagulação em pacientes cardiopatas
(Universidade Federal de Minas GeraisUFMG, 2017-03-31)
Warfarin is widely used in the prevention of thromboembolic events. The International Normalized Ratio (INR) is the parameter of choice for monitoring the response to warfarin and Time in Therapeutic Range (TTR) is used ...
VKORC1 polymorphisms in Brazilians: comparison with the Portuguese and Portuguese-speaking Africans and pharmacogenetic implications
(FUTURE MEDICINE LTD, 2010)
Aims: The heterogeneity of the Brazilian population renders the extrapolation of pharmacogenomic data derived from well-defined ethnic groups inappropriate. We investigated the influence of self-reported `race/color`, ...
Algorithm for predicting low maintenance doses of warfarin using age and polymorphisms in genes CYP2C9 and VKORC1 in Brazilian subjects
(Universidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICX - DEPARTAMENTO DE ESTATÍSTICAMED - DEPARTAMENTO DE CLÍNICA MÉDICAUFMG, 2019)
A varfarina apresenta uma ampla variação nos requisitos de dose. Buscamos avaliar a associação dos polimorfismos CYP2C9*2 (rs1799853), CYP2C9*3 (rs1075910) e VKORC1-G1639A (rs9923231) e fatores não genéticos com doses de ...
Risk-assessment algorithm and recommendations for venous thromboembolism prophylaxis in medical patients
(2007-10-16)
The risk for venous thromboembolism (VTE) in medical patients is high, but risk assessment is rarely performed because there is not yet a good method to identify candidates for prophylaxis. Purpose: To perform a systematic ...
Risk-assessment algorithm and recommendations for venous thromboembolism prophylaxis in medical patients
(2007-10-16)
The risk for venous thromboembolism (VTE) in medical patients is high, but risk assessment is rarely performed because there is not yet a good method to identify candidates for prophylaxis. Purpose: To perform a systematic ...