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Desenvolvimento de sistemas nanoestruturados à base de óleo de pracaxi contendo ubiquinona e avaliação da citotoxicidade in vitro
(Universidade Federal de Santa MariaBRFarmáciaUFSMPrograma de Pós-Graduação em Ciências Farmacêuticas, 2014-03-27)
This work aimed the preparation of novel nanocapsules and nanoemulsions based on pracaxy oil loaded with ubiquinone. For nanocapsules, poly(-caprolactone) (PCL) or Eudragit® EPO were employed in the preparation. For ...
Solanesyl diphosphate synthase, an enzyme of ubiquinone synthetic pathway, is required throughout the life cycle of Trypanosoma brucei
(American Society For Microbiology, 2014-02)
Ubiquinone 9 (UQ9), the expected product of the long-chain solanesyl diphosphate synthase of Trypanosoma brucei (TbSPPS), has a central role in reoxidation of reducing equivalents in the mitochondrion of T. brucei. The ...
The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
Farnesol (FOH) is a nonsterol isoprenold produced by dephosphorylanon of farnesyl pyrophosphate a catabolite of the cholesterol biosynthetic pathway These isoprenoids inhibit proliferation and induce apoptosis Here we show ...
Modelagem molecular aplicada ao desenvolvimento de moléculas com atividade antioxidante visando ao uso cosmético
(2007-04-01)
Some hypotheses and constants studies are made with intention to elucidate the aging process. To prevent and to attenuate the cutaneous aging it becomes necessary to strengthen our endogenous antioxidant natural defenses. ...
Modelagem molecular aplicada ao desenvolvimento de moléculas com atividade antioxidante visando ao uso cosmético
(2007-04-01)
Some hypotheses and constants studies are made with intention to elucidate the aging process. To prevent and to attenuate the cutaneous aging it becomes necessary to strengthen our endogenous antioxidant natural defenses. ...
Inhibition of mitochondrial complex i by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action
(2012)
Mitochondrial dysfunction plays a major role in the development of oxidative stress and cytotoxicity induced by non-steroidal anti-inflammatory drugs (NSAIDs). A major objective of the present study was to investigate ...