Artículos de revistas
The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance
Fecha
2010Registro en:
FUNGAL GENETICS AND BIOLOGY, v.47, n.12, p.1055-1069, 2010
1087-1845
10.1016/j.fgb.2010.07.006
Autor
DINAMARCO, Taisa Magnani
PIMENTEL, Barbara de Castro Figueiredo
SAVOLDI, Marcela
MALAVAZI, Iran
SORIANI, Frederico Marianetti
UYEMURA, Sergio Akira
LUDOVICO, Paula
GOLDMAN, Maria Helena S.
GOLDMAN, Gustavo Henrique
Institución
Resumen
Farnesol (FOH) is a nonsterol isoprenold produced by dephosphorylanon of farnesyl pyrophosphate a catabolite of the cholesterol biosynthetic pathway These isoprenoids inhibit proliferation and induce apoptosis Here we show that Aspergillus nidulans MA encoding the apoptosis-Inducing factor (AIF)-like mitochondrial oxidoreductase plays a role in the function of the mitochondrial Complex I Additionally we demonstrated that ndeA B and ndiA encode external and internal alternative NADH dehydrogenases respectively that have a function in FOH resistance When exposed to FOH the Delta aifA and Delta ndeA strains have increased ROS production while Delta ndeB Delta ndeA Delta ndeB and Andul mutant strains showed the same ROS accumulation than in the absence of FOH We observed several compensatory mechanisms affecting the differential survival of these mutants to FOH (C) 2010 Elsevier Inc All rights reserved