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Proinflammatory response of canine trophoblasts to Brucella canis infection
(Public Library of Science, 2017-10)
Brucella canis infection is an important cause of late-term abortion in pregnant bitches. The pathophysiological mechanisms leading to B. canis–induced abortion are unknown, but heavily infected trophoblasts are consistently ...
Impairment of first-trimester trophoblast cell function by ZIKV infection. Role of VIP in the trophoblast response to the virus.
(Elsevier, 2019)
: Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and altered central nervous system development. We have previously demonstrated that the vasoactive intestinal peptide ...
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection
(Academic Press-Elsevier, 2016)
Congenital Chagas disease is caused by the protozoan parasite Trypanosoma cruzi that must cross the placental barrier during transmission. The trophoblast constitutes the first tissue in contact with the maternal-blood ...
Proinflammatory response of human trophoblastic cells to Brucella abortus infection and upon interactions with infected phagocytes
(Society for the Study of Reproduction, 2016-02)
Trophoblasts are targets of infection by Brucella spp. but their role in the pathophysiology of pregnancy complications of brucellosis is unknown. Here we show that Brucella abortus invades and replicates in the human ...
Ex vivo infection of human placental explants by trypanosoma cruzi reveals a microRNA profiles Similar to that seen in trophoblast differentiation
(MDPI, 2022)
Congenital Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is responsible for 22.5% of new cases each year. However, placental transmission occurs in only 5% of infected mothers and it has been proposed ...
Impact of the Placental Cytokine-Chemokine Balance on Regulation of Cell-Cell Contact-Induced Human Immunodeficiency Virus Type 1 Translocation across a Trophoblastic Barrier In Vitro
(American Society for Microbiology, 2005-10)
Cells constituting the placental barrier secrete soluble factors that may participate in controlling human immunodeficiency virus type 1 (HIV-1) transmission from the mother to the fetus. In this study, we asked whether ...