info:eu-repo/semantics/publishedVersion
Impairment of first-trimester trophoblast cell function by ZIKV infection. Role of VIP in the trophoblast response to the virus.
Fecha
2019Registro en:
Impairment of first-trimester trophoblast cell function by ZIKV infection. Role of VIP in the trophoblast response to the virus.; International Federation of Placenta Association Meeting; Buenos Aires; Argentina; 2019; e89-e89
0143-4004
CONICET Digital
CONICET
Autor
Vota, Daiana Marina
Paparini, Daniel Esteban
Torti, Maria Florencia
Merech, Fátima Isabel
Hauk, Vanesa Cintia
Giovannoni, Federico
Calo, Guillermina
Ramhorst, Rosanna Elizabeth
Garcia, Cybele
Perez Leiros, Claudia
Resumen
: Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and altered central nervous system development. We have previously demonstrated that the vasoactive intestinal peptide (VIP) favors immune homeostasis maintenance and increases trophoblast cell (Tb) migration at early pregnancy. Our aim is to study the mechanisms of ZIKV infection in first-trimester human Tb cells and the effect of VIP in the Tb response to the virus