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Expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi is spatially restricted to zones of cell proliferation
(2014-04-24)
Abstract
Background
The Sox genes, a family of transcription factors characterized by the presence of a high mobility group (HMG) box domain, are among the central groups of developmental regulators ...
Dynamical reorganization of the pluripotency transcription factors Oct4 and Sox2 during early differentiation of embryonic stem cells
(Nature, 2020-03)
Pluripotency maintenance requires transcription factors (TFs) that induce genes necessary to preserve the undifferentiated state and repress others involved in differentiation. Recent observations support that the heterogeneous ...
The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
(Nature Publishing Group, 2018)
© 2018, The Author(s). Precise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections ...
In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures
(Oxford University Press, 2017-07)
In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9, we combined analysis of SOX9-bound ...
A expressão de SOX3 modula as vias de apoptose e transição epitélio-mesênquima em carcinoma ductal invasivo de mama humano
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em PatologiaUFMG, 2022-02-24)
Breast cancer is one of the diseases that kill most women worldwide. It is considered a complex
disease with dynamic behavior, it is necessary to search for new tumor markers and therapeutic
targets. Proteins that act ...
Marcador de células-tronco SOX2 é amplamente expresso em células da granulosa luteinizada humana de mulheres submetidas à estimulação ovariana controlada
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE PATOLOGIAPrograma de Pós-Graduação em PatologiaUFMG, 2021-05-27)
The human ovary is responsible for providing mature and competent reproductive oocytes and contains cells that exhibit stem cell markers, including a subpopulation of granulosa cells (GC). Inhibins can be considered a ...
SOX11 expression in chronic lymphocytic leukemia correlates with adverse prognostic markers
(Springer, 2015-01)
The transcription factor SOX11 plays an important role in embryonic neurogenesis and tissue remodeling. Recent studies have shown aberrant expression of SOX11 in various types of aggressive B cell neoplasms. In this study, ...
SOX-11 regulates LINE-1 retrotransposon activity during neuronal differentiation
(Federation of European Biochemical Societies, 2018-11)
Activity of the human long interspersed nuclear elements-1 (LINE-1) retrotransposon occurs mainly in early embryonic development and during hippocampal neurogenesis. SOX-11, a transcription factor relevant to neuronal ...