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Evolución del mecanismo de intercambio de segmentos en la subfamilia FoxP de factores de transcripción humanos
(Universidad de Chile, 2021)
Las proteínas Fox son una familia de factores de transcripción cuyo dominio de unión a ADN existe canónicamente como monómeros en solución. Sin embargo, las estructuras de FoxP2 y FoxP3, dos proteínas que son miembros de ...
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
(ROCKEFELLER UNIV PRESS, 2007-06-25)
We demonstrate that all-trans retinoic acid (RA) induces FoxP3 adaptive T regulatory
cells (A-Tregs) to acquire a gut-homing phenotype ( 4 7 CC chemokine receptor 9 )
and the capacity to home to the lamina ...
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
(2007)
We demonstrate that all-trans retinoic acid (RA) induces Ill adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype (alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to the lamina ...
Cryopreservation modulates the detection of regulatory T cell markers
(Wiley, 2012)
Background: Regulatory T cells (Tregs) modulate the host response in infectious diseases and are key mediators of peripheral tolerance. Cryopreservation of peripheral blood mononuclear cells (PBMCs) is commonly used in ...
Therapeutic blockade of Foxp3 in experimental breast cancer models
(Springer, 2017-11)
Purpose: Regulatory T cells (Tregs) impair the clinical benefit of cancer immunotherapy. To optimize the antitumor efficacy of therapeutic dendritic cell (DC) vaccines, we aimed to inhibit Foxp3, a transcription factor ...
Normalization of FoxP3+ regulatory T cells in response to effective antiretroviral therapy
(Oxford University Press, 2011)
Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype ...