Article
CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor
Registro en:
CHISSUMBA, Raquel Matavele et al. CD4+CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor. BMC Immunology, v. 16, n. 52, p. 1-9, 2015.
1471-2172
10.1186/s12865-015-0116-x
Autor
Matavele Chissumba, Raquel
Barbosa, Suse Dayse Silva
Augusto, Ângelo
Maueia, Cremildo
Mabunda, Nédio
Gudo Jr., Eduardo Samo
Bhatt, Nilesh
Jani, Ilesh
Savino, Wilson
Resumen
Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-infection are more prone to develop neurological complications. The aim of this study was to characterize phenotypically Treg cells in HIV-1/HTLV-1 co-infected Mozambican individuals presenting neurological symptoms.