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A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance
(Elsevier Science, 2012-10)
Adenosine A1 receptor antagonists are of potential value in the treatment of cognitive dysfunction. We have developed compound AJ23 (7-methyl-1-phenyl-1,8-dihydro-pyrazolo-(3,4d)(1,2,4)-triazolo(1,5a)-pyrimidin-4-one) as ...
Bacillus sp. strains and their inducible in vitro antagonism : a biochemical and molecular study
(Universidad EAFITDoctorado en IngenieríaEscuela de IngenieríaMedellín, 2018)
Discovering novel antibiotic substances from natural sources and revitalizing the pipeline for
screenings of naturally sourced substances that could render new bioactive compounds, is a
priority nowadays in the face of ...
Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
(2011-04-01)
Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. ...
Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
(2011-04-01)
Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. ...
Síntesis y estudio fotofísico de análogos del Prodan con sistema [pi]-extendido de pirazolo[1,5-a]pirimidina
(Universidad de los AndesMaestría en QuímicaFacultad de CienciasDepartamento de Química, 2022-12-06)
En este trabajo de investigación se obtuvieron sondas fluorescentes basadas en el núcleo heterocíclico pi-extendido de pirazolo[1,5-a]pirimidina (PP) con potencial aplicación en el marcado de biomoléculas. Considerando las ...
Influence of diet on oxidative DNA damage, uracil misincorporation and DNA repair capability
(Oxford University Press, 2010-09-01)
The contribution of diet to cancer ranges from 10 to 80%. The low ingestion of antioxidants and enzymatic cofactors involved in DNA repair and methylation reactions and the high ingestion of chemical additives present in ...