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INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
(Wiley, 2007)
The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16INK4a, p15INK4b, p18INK4c, and ...
Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors
(FUNPEC-EDITORA, 2008)
The cancer is one of the most common and severe problems in clinical medicine, and nervous system tumors represent about 2% of the types of cancer. The central role of the nervous system in the maintenance of vital activities ...
Transcriptional upregulation of p19INK4d upon diverse genotoxic stress is critical for optimal DNA damage response
(Elsevier, 2008-12)
p19INK4d promotes survival of several cell lines after UV irradiation due to enhanced DNA repair, independently of CDK4 inhibition. To further understand the action of p19INK4d in the cellular response to DNA damage, we ...
p16 INK 4a and Ki-67 expression in human papilloma virus-related head and neck mucosal lesions.
(Universidad del Zulia, 2015)
Prognostic markers of high-grade squamous intraepithelial lesions: the role of p16(INK4a) and high-risk human papillomavirus
(Taylor & Francis AsOsloNoruega, 2007)
Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions
(2005-04-01)
Inactivation of the cell cycle inhibitor gene p16MTS1 seems to be involved in human papillomavirus (HPV)-related carcinogenesis because E6 and E7 oncoproteins may impair p16INK4a and, indirectly, bcl-2 functions. In this ...
Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats
(2002-04-04)
Abstract
Background
The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma ...