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DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway
(Elsevier B.V., 2018-03-01)
MLH1 and PMS2 proteins form the MutLa heterodimer, which plays a major role in DNA mismatch repair (MMR) in humans. Mutations in MMR-related proteins are associated with cancer, especially with colon cancer. The N-terminal ...
Biophysical Characterization of the Recombinant Importin-alpha from Neurospora crassa
(Bentham Science Publ Ltd, 2013-01-01)
Neurospora crassa has been widely used as a model organism and contributed to the development of biochemistry and molecular biology by allowing the identification of many metabolic pathways and mechanisms responsible for ...
Nuclear action of FGF members in endocrine-related tissues and cancer: interplay with steroid receptor pathways
(Elsevier Science Inc, 2019-09)
Dysregulation of the fibroblast growth factors/fibroblast growth factor receptor (FGF/FGFR) pathway has been implicated in a wide range of human disorders and several members have been localized in the nuclear compartment. ...
Structural and Calorimetric Studies Demonstrate that Xeroderma Pigmentosum Type G (XPG) Can Be Imported to the Nucleus by a Classical Nuclear Import Pathway via a Monopartite NLS Sequence
(Elsevier B.V., 2016-05-22)
Xeroderma pigmentosum type G (XPG) proteins are involved in DNA lesion recognition and promotion of nucleotide excision repair. Specific mutations in these proteins may lead to Cockayne syndrome, in which the patients may ...
Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80
(Academic Press Ltd Elsevier B.V. Ltd, 2011-09-16)
Ku70 and Ku80 form a heterodimeric complex involved in multiple nuclear processes. This complex plays a key role in DNA repair due to its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous ...
Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80
(Academic Press Ltd Elsevier B.V. Ltd, 2011-09-16)
Ku70 and Ku80 form a heterodimeric complex involved in multiple nuclear processes. This complex plays a key role in DNA repair due to its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous ...
Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80
(Academic Press Ltd Elsevier B.V. Ltd, 2014)
Structural Biology and Regulation of Protein Import into the Nucleus
(Elsevier B.V., 2016-05-22)
Proteins are translated in the cytoplasm, but many need to access the nucleus to perform their functions. Understanding how these nuclear proteins are transported through the nuclear envelope and how the import processes ...
Biophysical characterization of the recombinant importin-α from neurospora crassa
(2013-02-01)
Neurospora crassa has been widely used as a model organism and contributed to the development of biochemistry and molecular biology by allowing the identification of many metabolic pathways and mechanisms responsible for ...
Biophysical characterization of the recombinant importin-α from neurospora crassa
(2013-02-01)
Neurospora crassa has been widely used as a model organism and contributed to the development of biochemistry and molecular biology by allowing the identification of many metabolic pathways and mechanisms responsible for ...