info:eu-repo/semantics/article
Nuclear action of FGF members in endocrine-related tissues and cancer: interplay with steroid receptor pathways
Fecha
2019-09Registro en:
Figueroa, Virginia; Rodriguez, Maria Sol; Lanari, Claudia Lee Malvina; Lamb, Caroline Ana; Nuclear action of FGF members in endocrine-related tissues and cancer: interplay with steroid receptor pathways; Elsevier Science Inc; Steroids; 9-2019
0039-128X
CONICET Digital
CONICET
Autor
Figueroa, Virginia
Rodriguez, Maria Sol
Lanari, Claudia Lee Malvina
Lamb, Caroline Ana
Resumen
Dysregulation of the fibroblast growth factors/fibroblast growth factor receptor (FGF/FGFR) pathway has been implicated in a wide range of human disorders and several members have been localized in the nuclear compartment. Hormone-activated steroid receptors or ligand independent activated receptors form nuclear complexes that activate gene transcription. This review aims to highlight the interplay between the steroid receptor and the FGF/FGFR pathways and focuses on the current knowledge on nuclear action of FGF members in endocrine-related tissues and cancer. The nuclear trafficking and targets of FGF/FGFR members and the available evidence on the interplay with steroid hormones and receptors is described. Finally, the data on aberrant FGF/FGFR signaling is summarized and the nuclear action of FGF members on endocrine resistant breast cancer is highlighted. Identifying the mechanisms underlying FGF-induced endocrine resistance will be important to understand how to efficiently target endocrine-related diseases and even enhance or restore endocrine sensitivity in hormone receptor positive tumors.