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Lithium decreases the effects of neuronal calcium sensor protein 1 on pedunculopontine neurons
(Physiological Society, 2016-03)
Human postmortem studies reported increased expression of neuronal calcium sensor protein 1 (NCS-1) in the brains of some bipolar disorder patients, and reduced or aberrant gamma band activity is present in the same disorder. ...
Pedunculopontine arousal system physiology - Implications for schizophrenia
(Elsevier Science, 2015-06)
Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal-related symptoms include sensory gating ...
Pedunculopontine arousal system physiology – implications for insomnia
(Elsevier Science, 2015-04)
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly ...
Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: Relevance to schizophrenia and bipolar disorder
(American Physiological Society, 2015-02)
Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem ...
Pedunculopontine nucleus gamma band activity-preconscious awareness, waking, and REM sleep
(Frontiers, 2014-10)
The pedunculopontine nucleus (PPN) is a major component of the reticular activating system (RAS) that regulates waking and REM sleep, states of high-frequency EEG activity. Recently,we described the presence of high ...
Envolvimento da proteína neuronal sensora de cálcio-1 (NCS-1) na sinalização muscarínica em células PC12
(Universidade Federal de Minas GeraisUFMG, 2007-06-19)
Neuronal calcium sensor-1 (NCS-1) belongs to the superfamily of EF-hand Ca2+ binding protein. Overexpression of NCS-1 was implicated on potentiation of synaptic transmission and plasticity in many experimental models. In ...
Fármacos estabilizadores do humor regulam a expressão do sensor neuronal de cálcio 1 (NCS-1)
(Universidade Federal de Minas GeraisUFMG, 2012-09-26)
Mood stabilizers (MSDs) represent a class of drugs commonly prescribed for bipolar disorder (BD) treatment though the molecular mechanisms underlying their actions remain to be identified. The aim of this study was to ...
Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside
(Elsevier Science, 2019-02)
GM2-gangliosidosis, a subgroup of lysosomal storage disorders, is caused by deficiency of hexosaminidase activity, and comprises the closely related Tay-Sachs and Sandhoff diseases. The enzyme deficiency prevents normal ...
Avaliação da expressão de moléculas envolvidas em neuroinflamação e neuromodulação em Wistar Audiogenic Rats
(Universidade Federal de Minas GeraisUFMG, 2016-03-19)
Seizures and epilepsy are neurological disorders extremely frequent in clinical practice. Neuronal mechanisms that constitutes the hyperexcitability and epileptogenesis phenomenon are not totally elucidated. It´s well known ...
Calcineurin β protects brain after injury by activating the unfolded protein response
(Academic Press Inc Elsevier Science, 2016-10)
The Ca2 +-dependent phosphatase, calcineurin (CN) is thought to play a detrimental role in damaged neurons; however, its role in astrocytes is unclear. In cultured astrocytes, CNβ expression increased after treatment with ...