Artículos de revistas
Pedunculopontine arousal system physiology – implications for insomnia
Fecha
2015-04Registro en:
Garcia Rill, Edgar; Luster, Brennon; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose; Pedunculopontine arousal system physiology – implications for insomnia; Elsevier Science; Sleep Science; 8; 2; 4-2015; 92-99
1984-0063
Autor
Garcia Rill, Edgar
Luster, Brennon
Mahaffey, Susan
Bisagno, Veronica
Urbano Suarez, Francisco Jose
Resumen
We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.