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The role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: Evidence from calretinin and neo-timm staining in pilocarpine-epileptic mice
(Lippincott Williams & Wilkins, 2000-01-01)
Mossy fiber sprouting is a major anatomical reorganization seen in patients with temporal lobe epilepsy and animal models of epilepsy. the final outcome of this reorganization is viewed by many as epileptogenic. Yet, ...
Hippocampal mossy fiber sprouting induced by forced and voluntary physical exercise
(Elsevier B.V., 2010-09-01)
Alterations in the function and organization of synapses have been proposed to induce learning and memory. Previous studies have demonstrated that mossy fiber induced by overtraining in a spatial learning task can be related ...
Manganese-enhanced magnetic resonance imaging detects mossy fiber sprouting in the pilocarpine model of epilepsy
(WILEY-BLACKWELLHOBOKEN, 2012)
Purpose: Mossy fiber sprouting (MFS) is a frequent finding following status epilepticus (SE). The present study aimed to test the feasibility of using manganese-enhanced magnetic resonance imaging (MEMRI) to detect MFS in ...
Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat
(Elsevier B.V., 1998-09-01)
In a previous study, we suggested a dissociation between spontaneous recurrent epileptic seizures (SRS) and hippocampal supragranular mossy fiber sprouting (MFS) in the pilocarpine model of epilepsy (PILO). One possible ...
Mesial temporal lobe epilepsy: Clinical and neuropathologic findings of familial and sporadic forms
(BLACKWELL PUBLISHING, 2008)
Purpose: To evaluate the clinical and hippocampal histological features of patients with mesial temporal lobe epilepsy (MTLE) in both familial (FMTLE) and sporadic (SMTLE) forms. Methods: Patients with FMTLE (n = 20) and ...
The pilocarpine model of epilepsy in mice
(Wiley-Blackwell, 1996-10-01)
Purpose: To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.Methods: After status epilepticus, the surviving animals were continuously ...
Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus
(Wiley-Blackwell, 2000-01-01)
Dentate granule cells are generally considered to be relatively resistant to excitotoxicity and have been associated with robust synaptogenesis after neuronal damage. Synaptic reorganization of dentate granule cell axons, ...
DECREASED NEURON LOSS AND MEMORY DYSFUNCTION IN PILOCARPINE-TREATED RATS PRE-EXPOSED TO HYPOXIA
(Elsevier B.V., 2016-09-22)
Preconditioning can induce a cascade of cellular events leading to neuroprotection against subsequent brain insults. In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent ...
Effect of long-term spontaneous recurrent seizures or reinduction of status epilepticus on the development of supragranular mossy fiber sprouting.
(Lippincott Williams & Wilkins, 1999-01-01)