Artigo
The pilocarpine model of epilepsy in mice
Fecha
1996-10-01Registro en:
Epilepsia. Malden: Wiley-Blackwell, v. 37, n. 10, p. 1015-1019, 1996.
0013-9580
10.1111/j.1528-1157.1996.tb00541.x
WOS:A1996VH59100016
Autor
Cavalheiro, E. A.
Santos, N. F.
Priel, M. R.
Institución
Resumen
Purpose: To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.Methods: After status epilepticus, the surviving animals were continuously monitored for 24 h/day for less than or equal to 120 days. the brains were processed by using neo-Timm and Nissl stains.Results: the first spontaneous seizures occurred between 4 and 42 days after status epilepticus. the mean ''seizure-silent period'' lasted for 14.4 +/- 11.9 days. During the chronic phase, recurrent spontaneous seizures were observed 1-5 times per animal per week and were associated with sprouting in the supragranular layer of the dentate gyrus.Conclusions: Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice.