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Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach
(Elsevier B.V., 2016-08-15)
We present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two ...
Rates of Chlorimuron Applied in Glyphosate-Tolerant and Sulfonylurea-Tolerant Soybean
(2018-09-01)
Susceptibility to chlorimuron varies according to soybean genotype. STS® (sulfonylurea-tolerant soybean) presents a high tolerance to some sulfonylureas; this feature is determined by semi-dominants alleles, Als1 and Als2. ...
Estudo do impacto da escolha do modelo para o controle de overdose na fase I dos ensaios clínicos
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Estatística - PIPGEsCâmpus São Carlos, 2018-10-03)
Escalation with overdose control proportional hazards is a Bayesian method with overdose control that estimates the maximum tolerated dose (MTD) assuming that the time a patient takes to show toxicity follows the proportional ...
Modelos matemáticos de câncer e imunoterapia
(Universidade Estadual Paulista (Unesp), 2019-11-11)
The incidence of neoplastic diseases shows that the search for more effective cancer treatments is still necessary. In addition to conventional treatments such as chemotherapy and radiotherapy, has been studied an alternative ...
Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy
(2013-06-01)
Given that cancer is one of the main causes of death worldwide, many efforts have been directed toward discovering new treatments and approaches to cure or control this group of diseases. Chemotherapy is the main treatment ...
Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy
(2013-06-01)
Given that cancer is one of the main causes of death worldwide, many efforts have been directed toward discovering new treatments and approaches to cure or control this group of diseases. Chemotherapy is the main treatment ...
Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Adults in an Open-Label Phase 1 Multiple Ascending Dose and Food Effect Study
(American Society for Microbiology, 2020)
Neurocysticercosis and trichuriasis are difficult-to-treat parasitic infections that affect more than 1.5 billion people worldwide. Oxfendazole, a potent broad-spectrum benzimidazole anthelmintic approved for use in ...
Pharmacokinetics, safety, and tolerability of oxfendazole in healthy volunteers: A randomized, placebo-controlled first-inhuman single-dose escalation study
(American Society for Microbiology, 2019)
Cysticercosis is a parasitic disease that frequently involves the human central nervous system (CNS), and current treatment options are limited. Oxfendazole, a veterinary medicine belonging to the benzimidazole family of ...
Popcorn (Zea mays L. var. everta) yield and yield components as influenced by the timing of broadcast flaming
(Elsevier B.V., 2010-12-01)
Farmers are interested in producing popcorn under organic production systems and propane flaming could be a significant component of an integrated weed management program. The objective of this study was to collect baseline ...