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Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions
(Elsevier Science London, 2015-06)
Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural ...
Computational prediction of short linear motifs from protein sequences
(Springer, 2015-01)
Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. SLiMs usually occur in structurally disordered ...
Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein
(Academic Press Inc Elsevier Science, 2018-12)
E1A is the main transforming protein in mastadenoviruses. This work uses bioinformatics to extrapolate experimental knowledge from Human adenovirus serotype 5 and 12 E1A proteins to all known serotypes. A conserved domain ...
QSLiM Finder: Improved short linear motif prediction using specific query protein data
(Oxford University Press, 2015-03)
Motivation: The sensitivity of de novo short linear motif (SLiM) prediction is limited by the number of patterns (the motif space) being assessed for enrichment. QSLiMFinder uses specific query protein information to ...
Thousands of protein linear motif classes may still be undiscovered
(Public Library of Science, 2021-05-03)
Linear motifs are short protein subsequences that mediate protein interactions. Hundreds of motif classes including thousands of motif instances are known. Our theory estimates how many motif classes remain undiscovered. ...
The articles.ELM resource: Simplifying access to protein linear motif literature by annotation, text-mining and classification
(Oxford University Press, 2020-01)
Modern biology produces data at a staggering rate. Yet, much of these biological data is still isolated in the text, figures, tables and supplementary materials of articles. As a result, biological information created at ...
ELM—the eukaryotic linear motif resource in 2020
(Oxford University Press, 2019-11)
The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource ...
The eukaryotic linear motif resource - 2018 update
(Oxford University Press, 2018-01)
Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear ...
The eukaryotic linear motif resource ELM: 10 years and counting
(Oxford University Press, 2014-01)
The eukaryotic linear motif (ELM http://elm.eu.org) resource is a hub for collecting, classifying and curating information about short linear motifs (SLiMs). For >10 years, this resource has provided the scientific community ...
Understanding the role of protein interaction motifs in transcriptional regulators: implications for crop improvement
(Oxford University Press, 2017-05-09)
Recently, the conjunction of disciplines such as developmental biology and proteomics enabled the dissection of diverse cellular processes, by analysis of their transcriptional regulatory pathways. In particular, it has ...