Artículos de revistas
Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions
Date
2015-06Registration in:
Chemes, Lucia Beatriz; de Prat Gay, Gonzalo; Sánchez Miguel, Ignacio Enrique; Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions; Elsevier Science London; Current Opinion In Structural Biology; 32; 6-2015; 91-101
0959-440X
Author
Chemes, Lucia Beatriz
de Prat Gay, Gonzalo
Sánchez Miguel, Ignacio Enrique
Abstract
Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functional output of a mimic depends on the motif and domain repertoire of the pathogen protein. Regulatory evolution mediated by linear motifs can be understood by measuring evolutionary rates, quantifying positive and negative selection and performing phylogenetic reconstructions of linear motif natural history. Convergent evolution of linear motif mimics is widespread among unrelated proteins from viral, prokaryotic and eukaryotic pathogens and can also take place within individual protein phylogenies. Statistics, biochemistry and laboratory models of infection link pathogen linear motifs to phenotypic traits such as tropism, virulence and oncogenicity. In vitro evolution experiments and analysis of natural sequences suggest that changes in linear motif composition underlie pathogen adaptation to a changing environment.