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Insight into nanoparticle cellular uptake and intracellular targeting
(2014)
Collaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in ...
Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms
(Frontiers, 2013-09-30)
Autophagy is involved in several physiological and pathological processes. One of the key roles of the autophagic pathway is to participate in the first line of defense against the invasion of pathogens, as part of the ...
Lipossomas: Estrategia biotecnologica para liberacao controlada e direcionamento intracelular de farmacos com efeito antimicobacteriano
(1997-01-01)
This text highlights the state of research related with the application of liposomes in the control of drug delivery and drug target to intracellular bacterial diseases, such as the tuberculosis. Liposome have several ...
Lipossomas: Estrategia biotecnologica para liberacao controlada e direcionamento intracelular de farmacos com efeito antimicobacteriano
(1997-01-01)
This text highlights the state of research related with the application of liposomes in the control of drug delivery and drug target to intracellular bacterial diseases, such as the tuberculosis. Liposome have several ...
Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Mycobacterium tuberculosis
(Frontiers Media Sa, 2018-08-21)
There is an urgent need to treat tuberculosis (TB) quickly, effectively and without side effects. Mycobacterium tuberculosis (Mtb), the causative organism of TB, can survive for long periods of time within macrophages and ...
Peptides and peptide-derived molecules targeting the intracellular domains of cx43: gap junctions versus hemichannels
(PERGAMON-ELSEVIER SCIENCE LTD, 2013)
Intracellular Blockers Design Targeting TASK-3 Potassium Channels
(2015)
TASK-‐3
is
a
two-‐pore
domain
potassium
(K2P)
channel
highly
expressed
in
hippocampus,
cerebellum
and
cortex.
TASK-‐3
regulates
neurotransmitter
functions
as
well
as
the
mediating
effect
of
the
neurotransmitter
activa ...
Oomycete intracellular effectors: Specialized weapons targeting strategic plant processes
(Wiley Blackwell Publishing, Inc, 2021-10-27)
Oomycete phytopathogens have adapted to colonise plants using effectors as their molecular weapons. Intracellular effectors, mostly proteins but also small ribonucleic acids, are delivered by the pathogens into the host ...
Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3e and calmodulin
(WILEY-BLACKWELLHOBOKEN, 2012)
Protein interactions are crucial for most cellular process. Thus, rationally designed peptides that act as competitive assembly inhibitors of protein interactions by mimicking specific, determined structural elements have ...
Intracellular signaling pathways involved in childhood acute lymphoblastic leukemia; molecular targets
(Indian Journal of Hematology and Blood Transfusion, 2020)