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Generation of neural progenitor cells from porcine-induced pluripotent stem cells
(Wiley-Blackwell, 2020-11-23)
In this study, porcine embryonic fibroblasts (pEFs) were reprogrammed into porcine-induced pluripotent stem cells (piPSCs) using either human or mouse specific sequences for the OCT4, SOX2, c-Myc, and KLF4 transcription ...
Improving Cell Recovery: Freezing and Thawing Optimization of Induced Pluripotent Stem Cells
(2022)
Achieving good cell recovery after cryopreservation is an essential process when working with induced pluripotent stem cells (iPSC). Optimized freezing and thawing methods are required for good cell attachment and survival. ...
Modulation of chromatin modifying factors' gene expression in embryonic and induced pluripotent stem cells
(Academic Press Inc Elsevier Science, 2011-07)
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are a promising source of cells for regenerative medicine because of their potential of self renew and differentiation. Multiple evidences highlight ...
Induced pluripotent stem cells' self-renewal and pluripotency is maintained by a bovine granulosa cell line-conditioned medium
(Academic Press Inc Elsevier Science, 2011-07)
Induced pluripotent stem cells (iPSCs) are a promising type of stem cells, comparable to embryonic stem cells (ESCs) in terms of self-renew and pluripotency, generated by reprogramming somatic cells. These cells are an ...
Generation of iPSC line iPSC-FH2.1 in hypoxic conditions from human foreskin fibroblasts
(Elsevier Science, 2016-01)
Human foreskin fibroblasts were used to generate the iPSC line iPSC-FH2.1 using the EF1a-hSTEMCCA-loxP vector expressing OCT4, SOX2, c-MYC and KLF4, in 5% O2 culture conditions. Stemness was confirmed, as was pluripotency ...
Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease
(Elsevier, 2015)
Monge’s disease, also known as chronic mountain sickness (CMS), is a disease that potentially threatens more than 140 million highlanders during extended time living at high altitudes (over 2500 m). The prevalence of CMS ...
Induced pluripotent stem cell-derived neural precursors improve memory, synaptic and pathological abnormalities in a mouse model of Alzheimer’s disease
(MDPI, 2021)
Alzheimer's disease (AD) is the most common type of dementia in the elderly population. The disease is characterized by progressive memory loss, cerebral atrophy, extensive neuronal loss, synaptic alterations, brain ...
Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient
(Elsevier, 2021-05)
Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male ...
Differentiation of porcine induced pluripotent stem cells (Pipscs) into neural progenitor cells (npcs)
(2021-06-01)
iPSC-derived neurons are attractive in vitro models to study neurogenesis and early phenotypic changes in mental illness, mainly when most animal models used in pre-clinical research, such as rodents, are not able to meet ...